Gene

fasn

ID
ZDB-GENE-030131-7802
Name
fatty acid synthase
Symbol
fasn Nomenclature History
Previous Names
  • FAS (1)
  • fj34h12
  • wu:fj34h12
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have several functions, including fatty acid synthase activity; hydrolase activity, acting on ester bonds; and phosphopantetheine binding activity. Involved in response to (R)-carnitine. Is expressed in liver and male organism. Orthologous to human FASN (fatty acid synthase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
51 figures from 46 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fasn Human Ortholog
No data available
Associated With fasn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018201 Beta-ketoacyl synthase, active site
Domain IPR001031 Thioesterase
Domain IPR009081 Phosphopantetheine binding ACP domain
Domain IPR013149 Alcohol dehydrogenase-like, C-terminal
Domain IPR013968 Polyketide synthase, ketoreductase domain
Domain IPR014030 Beta-ketoacyl synthase, N-terminal
Domain IPR014031 Beta-ketoacyl synthase, C-terminal
Domain IPR014043 Acyl transferase
Domain IPR020806 Polyketide synthase, phosphopantetheine-binding domain
Domain IPR020807 Polyketide synthase, dehydratase domain
Domain IPR020841 Polyketide synthase, beta-ketoacyl synthase domain
Domain IPR020843 Polyketide synthase, enoylreductase domain
Domain IPR032821 Polyketide synthase, C-terminal extension
Homologous_superfamily IPR001227 Acyl transferase domain superfamily
Homologous_superfamily IPR011032 GroES-like superfamily
Homologous_superfamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
Homologous_superfamily IPR016036 Malonyl-CoA ACP transacylase, ACP-binding
Homologous_superfamily IPR016039 Thiolase-like
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Homologous_superfamily IPR036736 ACP-like superfamily
Homologous_superfamily IPR042104 Polyketide synthase, dehydratase domain superfamily
PTM IPR006162 Phosphopantetheine attachment site
Domain Details Per Protein
Protein Length ACP-like superfamily Acyl transferase Acyl transferase/acyl hydrolase/lysophospholipase Acyl transferase domain superfamily Alcohol dehydrogenase-like, C-terminal Alpha/Beta hydrolase fold Beta-ketoacyl synthase, active site Beta-ketoacyl synthase, C-terminal Beta-ketoacyl synthase, N-terminal GroES-like superfamily Malonyl-CoA ACP transacylase, ACP-binding NAD(P)-binding domain superfamily Phosphopantetheine attachment site Phosphopantetheine binding ACP domain Polyketide synthase, beta-ketoacyl synthase domain Polyketide synthase, C-terminal extension Polyketide synthase, dehydratase domain Polyketide synthase, dehydratase domain superfamily Polyketide synthase, enoylreductase domain Polyketide synthase, ketoreductase domain Polyketide synthase, phosphopantetheine-binding domain S-adenosyl-L-methionine-dependent methyltransferase superfamily Thioesterase Thiolase-like
UniProtKB:E7F5V3 2514
UniProtKB:F8W3U6
UniProtKB:A0A8M9Q0T1 724
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations