ZFIN Gene: gas6

ZFIN ID: ZDB-GENE-030131-7773

ZFIN ID: ZDB-GENE-030131-7773

Gene Name:

growth arrest-specific 6

Gene Symbol:

gas6

Sequence Ontology ID :

SO:0001217

Previous Names:

fj34a12, wu:fj34a12, zgc:63860

Location:

Chr: 1 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have calcium ion binding activity. Involved in sprouting angiogenesis. Predicted to localize to the extracellular region. Is expressed in heart; nervous system; and neural tube. ...

GENE EXPRESSION
All Expression Data:	15 figures from 5 publications
Directly Submitted Expression Data:	6 figures (9 images) from Thisse et al., 2004 [MGC:63860]
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
	basal plate midbrain region diencephalon eye heart hindbrain lateral line ganglion neural tube neuron rhombomere rhombomere 5 rhombomere 6 spinal cord tegmentum unspecified whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa9012	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa19391	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa32572	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
stl228	Small Deletion	Exon 2	Frameshift, Premature Stop	CRISPR
um296	Small Deletion	Exon 1	Unknown	CRISPR
um297	Small Deletion	Exon 1	Unknown	CRISPR
um298	Small Deletion	Exon 1	Unknown	CRISPR
um299	Small Deletion	Exon 1	Unknown	CRISPR
zko14a	Small Deletion	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)
zko14b	Small Deletion	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)

Targeting reagents:

PHENOTYPE

Data:	3 figures from 2 publications
Observed in:	dorsal longitudinal anastomotic vessel intersegmental vessel rhombomere 5 rhombomere 6 sprouting angiogenesis

DISEASE ASSOCIATED WITH gas6 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH gas6 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	sprouting angiogenesis (more)
Cellular Component	extracellular region (more)
Molecular Function	calcium ion binding (more)

GO Terms (all 3)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000152 (1) InterPro:IPR000294 (1) InterPro:IPR000742 (1) InterPro:IPR001791 (1) InterPro:IPR001881 (1) InterPro:IPR009030 (1) InterPro:IPR013032 (1) InterPro:IPR013320 (1) InterPro:IPR017857 (1) InterPro:IPR018097 (1) InterPro:IPR035972 (1)	PROSITE:PS00010 (1) PROSITE:PS00011 (1) PROSITE:PS00022 (1) PROSITE:PS01186 (1) PROSITE:PS01187 (1) PROSITE:PS50025 (1) PROSITE:PS50026 (1) PROSITE:PS50998 (1)	Pfam:PF00008 (1) Pfam:PF00054 (1) Pfam:PF00594 (1) Pfam:PF02210 (1) Pfam:PF07645 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	gas6-201 (1)	2637	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM gas6 No data available

MARKER RELATIONSHIPS

gas6 Contained in:	[BAC] CH211-129C2 (1) (order this)
gas6 Encodes:	[EST] fj34a12 [cDNA] MGC:63860 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_199978 (1)	2472 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU179747 (1)	162432 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1QGG9 (1)	648 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:80253 (1)

Sequence Information (all 12)

OTHER gas6 GENE PAGES

Alliance (1)

Gene:335830 (1)

VEGA:OTTDARG00000027093 (1)

Ensembl(GRCz11):ENSDARG00000007804 (2)

ORTHOLOGY for gas6 ( Chr: 1 )

CITATIONS (23)

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