Gene

zgc:65894

ID
ZDB-GENE-030131-7741
Name
zgc:65894
Symbol
zgc:65894 Nomenclature History
Previous Names
  • fj33a08
  • wu:fj33a08
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in central nervous system; cranial ganglion; retina; retinal ganglion cell layer; and trigeminal placode. Human ortholog(s) of this gene implicated in Leber congenital amaurosis with early-onset deafness; complex cortical dysplasia with other brain malformations 6; and congenital symmetric circumferential skin creases 1. Orthologous to human TUBB4B (tubulin beta 4B class IVb) and TUBB (tubulin beta class I).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zgc:65894 Human Ortholog
No data available
Associated With zgc:65894 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR013838 Beta tubulin, autoregulation binding site
Conserved_site IPR017975 Tubulin, conserved site
Domain IPR003008 Tubulin/FtsZ, GTPase domain
Domain IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
Family IPR000217 Tubulin
Family IPR002453 Beta tubulin
Homologous_superfamily IPR008280 Tubulin/FtsZ, C-terminal
Homologous_superfamily IPR023123 Tubulin, C-terminal
Homologous_superfamily IPR036525 Tubulin/FtsZ, GTPase domain superfamily
Homologous_superfamily IPR037103 Tubulin/FtsZ, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Beta tubulin Beta tubulin, autoregulation binding site Tubulin Tubulin, conserved site Tubulin, C-terminal Tubulin/FtsZ, 2-layer sandwich domain Tubulin/FtsZ, C-terminal Tubulin/FtsZ, C-terminal domain superfamily Tubulin/FtsZ, GTPase domain Tubulin/FtsZ, GTPase domain superfamily
UniProtKB:Q6PE34 444
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations