Gene

cth

ID
ZDB-GENE-030131-774
Name
cystathionase (cystathionine gamma-lyase)
Symbol
cth Nomenclature History
Previous Names
  • fb58d08
  • wu:fb48e03 (1)
  • wu:fb58d08 (1)
  • zgc:66001 (1)
  • zgc:85785
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in cysteine biosynthetic process via cystathionine and transsulfuration. Predicted to act upstream of or within cysteine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cth Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cystathioninuria Alliance Cystathioninuria 219500
Associated With cth Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015422 Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Cys/Met metabolism, pyridoxal phosphate-dependent enzyme Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase, major domain Pyridoxal phosphate-dependent transferase, small domain
UniProtKB:F1QPF7 404
UniProtKB:Q6PHI6 400
UniProtKB:Q6NWE3 400
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations