ZFIN ID: ZDB-GENE-030131-7715
Gene Name: cytochrome c oxidase subunit 6A1
Gene Symbol: cox6a1    Nomenclature History

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Previous Names: ns:zf-e250, zgc:103782

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to contribute to cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to localize to mitochondrial respiratory chain complex IV. Is expressed in several structures, including alar plate midbrain region; brain; eye; liver; and muscle. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate D. Orthologous to human COX6A1 (cytochrome c oxidase subunit 6A1).
Genome Resources: Alliance (1),  Gene:335774 (1),  Ensembl(GRCz11):ENSDARG00000022438 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 2 publications
Directly Submitted Expression Data: 5 figures (8 images) from Thisse et al., 2004 [IMAGE:6896829]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cox6a1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease recessive intermediate D Alliance Charcot-Marie-Tooth disease, recessive intermediate D 616039
DISEASE ASSOCIATED WITH cox6a1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process aerobic respiration (more)
Cellular Component integral component of membrane (more)
Molecular Function cytochrome-c oxidase activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cox6a1-201 (1)    Ensembl 627
ncRNA cox6a1-002 (1)    Ensembl 703
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cox6a1 No data available
MARKER RELATIONSHIPS
cox6a1 Contained in: [BAC] CH211-170D8 (1)
cox6a1 Encodes: [EST] IMAGE:6896829 (1), zf-e250
[cDNA] MGC:103782 (1), MGC:192125 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001005592 (1) 639 nt
Genomic GenBank:CT027598 (1) 101489 nt
Select Tool
Polypeptide UniProtKB:A9C462 (1) 108 aa
Sequence Information (all 15)
ORTHOLOGY for cox6a1 ( Chr: 8 )
CITATIONS (25)