Gene

gsdmeb

ID
ZDB-GENE-030131-7662
Name
gasdermin Eb
Symbol
gsdmeb Nomenclature History
Previous Names
  • dfna5
  • dfna5b
  • fk59f08
  • wu:fc41e05
  • wu:fk59f08
  • zgc:91916 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Acts upstream of or within with a positive effect on pyroptosis. Acts upstream of or within inner ear morphogenesis and regulation of biosynthetic process. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; heart tube; hematopoietic system; nervous system; and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 5 and sensorineural hearing loss. Orthologous to human GSDME (gasdermin E).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gsdmeb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 5 Alliance Deafness, autosomal dominant 5 600994
Associated With gsdmeb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR040460 Gasdermin, pore forming domain
Domain IPR041263 Gasdermin, PUB domain
Family IPR042377 Gasdermin-E
Domain Details Per Protein
Protein Length Gasdermin-E Gasdermin, pore forming domain Gasdermin, PUB domain
UniProtKB:Q6J2R6 472
UniProtKB:E9QBE8 106
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations