ZFIN ID: ZDB-GENE-030131-7662
Gene Name: gasdermin Eb
Gene Symbol: gsdmeb    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: dfna5, dfna5b, fk59f08, wu:fc41e05, wu:fk59f08, zgc:91916 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Involved in inner ear morphogenesis and regulation of biosynthetic process. Is expressed in heart tube; intermediate cell mass of mesoderm; nervous system; neural crest; and otic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 5 and sensorineural hearing loss. Orthologous to human GSDME (gasdermin E).
Genome Resources: Alliance (1),  Gene:335722 (1),  Ensembl(GRCz11):ENSDARG00000040485 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 5 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [MGC:91916]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa36101 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42706 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gsdmeb
    2
    CRISPR2-gsdmeb
    2
    MO1-gsdmeb N/A 1
    MO2-gsdmeb N/A 1
    MO3-gsdmeb N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gsdmeb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 5 Alliance Deafness, autosomal dominant 5 600994
    DISEASE ASSOCIATED WITH gsdmeb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ear morphogenesis (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gsdmeb-201 (1)    Ensembl 2369
    gsdmeb-202 (1)    Ensembl 434
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gsdmeb No data available
    MARKER RELATIONSHIPS
    gsdmeb Contained in: [BAC] DKEY-15J7 (1) (order this)
    gsdmeb Encodes: [EST] fc41e05 (1), fk59f08
    [cDNA] MGC:91916
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001947 (1) 2350 nt
    Genomic GenBank:BX469919 (1) 219865 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q6J2R6 (1) 472 aa
    Sequence Information (all 21)
    ORTHOLOGY for gsdmeb ( Chr: 16 )
    CITATIONS (26)