ZFIN ID: ZDB-GENE-030131-7518
Gene Name: ADP ribosylation factor like GTPase 3b
Gene Symbol: arl3b    Nomenclature History

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Previous Names: arl3, si:ch211-208d15.4, wu:fj22g05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have GTPase activity; microtubule binding activity; and purine ribonucleoside binding activity. Involved in cilium assembly. Predicted to localize to several cellular components, including microtubule cytoskeleton; midbody; and photoreceptor connecting cilium. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa. Orthologous to human ARL3 (ADP ribosylation factor like GTPase 3).
Genome Resources: Alliance (1),  Gene:797451 (1),  Ensembl(GRCz11):ENSDARG00000071409 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a233 Small Deletion Unknown Unknown CRISPR
sa6267 Point Mutation Unknown Premature Stop ENU
sa35344 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-arl3b 1
    CRISPR2-arl3b 1
    CRISPR3-arl3b 1
    CRISPR4-arl3b 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH arl3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Joubert syndrome 35 618161
    Retinitis pigmentosa 83 618173
    DISEASE ASSOCIATED WITH arl3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cilium assembly (more)
    Cellular Component centrosome (more)
    Molecular Function GDP binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arl3-201 (1)    Ensembl 2396
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arl3b No data available
    MARKER RELATIONSHIPS
    arl3b Contained in: [BAC] CH211-208D15 (1), CH211-244C18 (1)
    arl3b Contains: [SNP] rs3728513 (1), rs3728514 (1), rs3728515 (1), rs3728516 (1)
    arl3b Encodes: [EST] fj22g05
    [cDNA] MGC:153602 (1), MGC:192140 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001044908 (1) 2404 nt
    Genomic RefSeq:NW_018394856 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:B2GR26 (1) 182 aa
    Sequence Information (all 22)
    ORTHOLOGY for arl3b ( Chr: 12 )
    CITATIONS (27)