header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030717-1
Gene Name: rho/rac guanine nucleotide exchange factor (GEF) 2
Gene Symbol: arhgef2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: fj11d04, si:ch211-198o19.3, wu:fj11d04 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have Rho guanyl-nucleotide exchange factor activity and metal ion binding activity. Predicted to be involved in intracellular signal transduction and regulation of Rho protein signal transduction. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2).
Genome Resources: Alliance (1),  Gene:561276 (1),  Ensembl(GRCz11):ENSDARG00000075819 (2)
GENE EXPRESSION
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22746 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22747 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH arhgef2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    neurodevelopmental disorder with midbrain and hindbrain malformations Alliance ?Neurodevelopmental disorder with midbrain and hindbrain malformations 617523
    DISEASE ASSOCIATED WITH arhgef2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular signal transduction (more)
    Molecular Function guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 3)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arhgef2-201 (1)    Ensembl 3993
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arhgef2 No data available
    MARKER RELATIONSHIPS
    arhgef2 Contained in: [BAC] CH211-198O19 (1) (order this)
    arhgef2 Encodes: [EST] fj11d04
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_684678 (1) 3768 bp
    Genomic GenBank:AL845419 (1) 176379 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q3N3 (1) 902 aa
    Sequence Clusters UniGene:122291 (1)
    Sequence Information (all 18)
    ORTHOLOGY for arhgef2 ( Chr: 16 )
    CITATIONS (16)