Gene

pcsk7

ID

ZDB-GENE-030131-7293

Name

proprotein convertase subtilisin/kexin type 7

Symbol

pcsk7 Nomenclature History

Previous Names

fj05c03
wu:fj05c03
zgc:158336

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have serine-type endopeptidase activity. Involved in brain development; chordate embryonic development; and sensory organ development. Predicted to localize to integral component of Golgi membrane and trans-Golgi network. Is expressed in several structures, including eye; gill; integument; liver; and pleuroperitoneal region. Orthologous to human PCSK7 (proprotein convertase subtilisin/kexin type 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Turpeinen et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pcsk7 Human Ortholog

No data available

Associated With pcsk7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR022398	Peptidase S8, subtilisin, His-active site
Active_site	IPR023827	Peptidase S8, subtilisin, Asp-active site
Active_site	IPR023828	Peptidase S8, subtilisin, Ser-active site
Domain	IPR000209	Peptidase S8/S53 domain
Domain	IPR002884	P domain
Domain	IPR032815	Peptidase S8, pro-domain
Domain	IPR034182	Kexin/furin catalytic domain
Family	IPR015500	Peptidase S8, subtilisin-related
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR036852	Peptidase S8/S53 domain superfamily
Homologous_superfamily	IPR038466	Peptidase S8, pro-domain superfamily