Gene

mak

ID
ZDB-GENE-030131-7279
Name
male germ cell-associated kinase
Symbol
mak Nomenclature History
Previous Names
  • fj04c02
  • wu:fj04c02
  • zgc:56603 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Predicted to be involved in cilium organization; intracellular signal transduction; and regulation of gene expression. Predicted to localize to cilium; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 62. Is expressed in Kupffer's vesicle; retina; and retinal photoreceptor layer. Orthologous to human MAK (male germ cell associated kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Tucker et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mak Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
retinitis pigmentosa 62 Alliance Retinitis pigmentosa 62 614181
Associated With mak Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:F1QUT2 633
UniProtKB:A0A8M9PFV2 590
UniProtKB:A0A8M3ANF8 600
UniProtKB:A0A8M2B9R2 601
UniProtKB:Q7ZTX0 633
UniProtKB:A0A286Y937 632
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations