ZFIN ID: ZDB-GENE-030131-7126
Gene Name: low density lipoprotein receptor-related protein 1Ab
Gene Symbol: lrp1ab    Nomenclature History

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Previous Names: lrp1, lrp1b, fk86b07, si:ch73-60e21.3, wu:fk86b07 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Involved in regulation of vasculature development. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1).
Genome Resources: Alliance (1),  Gene:565797 (1),  Ensembl(GRCz11):ENSDARG00000029146 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a293 Complex Unknown Unknown CRISPR
ihb392 Small Deletion Exon 12 Unknown CRISPR
ihb405 Small Deletion Exon 12 Unknown CRISPR
sa166 Point Mutation Unknown Premature Stop ENU
sa200 Point Mutation Unknown Premature Stop ENU
sa12511 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14527 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18116 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24341 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24342 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30741 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37716 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37717 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37718 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43990 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lrp1ab 1
    CRISPR2-lrp1ab 1
    CRISPR3-lrp1ab 1
    CRISPR4-lrp1ab 1
    CRISPR5-lrp1ab 1
    MO1-lrp1ab N/A 1
    DISEASE ASSOCIATED WITH lrp1ab HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Keratosis pilaris atrophicans 604093
    DISEASE ASSOCIATED WITH lrp1ab VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of vasculature development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lrp1ab-201 (1)    Ensembl 14019
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lrp1ab No data available
    MARKER RELATIONSHIPS
    lrp1ab Contained in: [BAC] CH73-60E21 (1), CH211-130P21 (1), DKEY-21C19 (1) (order this)
    lrp1ab Encodes: [EST] fk86b07
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005162219 (1) 15648 nt
    Genomic GenBank:BX005414 (1) 236036 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QY34 (1) 4549 aa
    Sequence Information (all 39)
    ORTHOLOGY for lrp1ab ( Chr: 23 )
    CITATIONS (20)