Gene

wasb

ID
ZDB-GENE-030131-7098
Name
WASP actin nucleation promoting factor b
Symbol
wasb Nomenclature History
Previous Names
  • was
  • wasp1 (1)
  • wu:fk81c08
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity. Involved in macrophage chemotaxis; neutrophil chemotaxis; and regulation of neutrophil migration. Predicted to localize to actin cortical patch and actin filament. Used to study Wiskott-Aldrich syndrome. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome and severe congenital neutropenia. Is expressed in hematopoietic system; leukocyte; neuromast; thrombocyte; and thymus. Orthologous to human WAS (WASP actin nucleation promoting factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wasb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thrombocytopenia Alliance Thrombocytopenia, X-linked 313900
thrombocytopenia Alliance Thrombocytopenia, X-linked, intermittent 313900
Wiskott-Aldrich syndrome Alliance Wiskott-Aldrich syndrome 301000
X-linked severe congenital neutropenia Alliance Neutropenia, severe congenital, X-linked 300299
Associated With wasb Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000095 CRIB domain
Domain IPR000697 WH1/EVH1 domain
Domain IPR003124 WH2 domain
Domain IPR033927 WASP family, EVH1 domain
Family IPR027641 Wiskott-Aldrich syndrome protein
Homologous_superfamily IPR011026 Wiscott-Aldrich syndrome protein, C-terminal
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR036936 CRIB domain superfamily
Domain Details Per Protein
Protein Length CRIB domain CRIB domain superfamily PH-like domain superfamily WASP family, EVH1 domain WH1/EVH1 domain WH2 domain Wiscott-Aldrich syndrome protein, C-terminal Wiskott-Aldrich syndrome protein
UniProtKB:B0S5G8 479
UniProtKB:B0S5G7 271
UniProtKB:Q7T318 479
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations