ZFIN ID: ZDB-GENE-030131-7098
Gene Name: Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b
Gene Symbol: wasb
Previous Names: was, wasp1 (1), wu:fk81c08
Location: Chr: 8 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (2 images) from Thisse et al., 2004 [MGC:64164]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  hematopoietic system, leukocyte, neuromast, thrombocyte (all 6) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3279 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hu3280 Point Mutation Unknown Unknown ENU
    sa1001 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16049 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34392 Point Mutation Unknown Unknown ENU
    Targeting reagents: MO1-wasb (1), MO2-wasb (1), MO3-wasb (1)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH wasb HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    severe congenital neutropenia Neutropenia, severe congenital, X-linked 300299
    thrombocytopenia Thrombocytopenia, X-linked 313900
    Thrombocytopenia, X-linked, intermittent 313900
    Wiskott-Aldrich syndrome Wiskott-Aldrich syndrome 301000
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process leukocyte chemotaxis (more)
    Molecular Function actin binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000095 (1)
  • InterPro:IPR000697 (1)
  • InterPro:IPR003124 (1)
  • InterPro:IPR011026 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR027641 (1)
  • PROSITE:PS50108 (1)
  • PROSITE:PS50229 (1)
  • PROSITE:PS51082 (1)
  • Pfam:PF00568 (1)
  • Pfam:PF00786 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA wasb-001 (1) 1735
    wasb-002 (1) 813
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM wasb No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    wasbContained in: [BAC] CH211-233C3 (1) (order this)
    wasbEncodes: [EST] fk81c08
    [cDNA] MGC:64164 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199938 (1) 1748bp
    Genomic GenBank:BX248384 (1) 155293bp
    Select Tool
    Polypeptide UniProtKB:B0S5G8 (1) 479aa
    Sequence Clusters UniGene:23314 (1)
    Sequence Information (all 12)
    OTHER wasb GENE PAGES
  • Gene:335158 (1)
  • VEGA:OTTDARG00000020215 (1)
  • Ensembl(GRCz10):ENSDARG00000026350 (1)
  • ORTHOLOGY for wasb (Chr: 8)
    Species Symbol Chromosome Accession # Evidence
    Human WAS X
  • Gene:7454
  • OMIM:300392
  • HGNC:12731
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Was X
  • MGI:105059
  • Gene:22376
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (24)