ZFIN ID: ZDB-GENE-030131-7098
Gene Name: WASP actin nucleation promoting factor b
Gene Symbol: wasb    Nomenclature History

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Previous Names: was, wasp1 (1), wu:fk81c08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Involved in macrophage chemotaxis; neutrophil chemotaxis; and regulation of neutrophil migration. Predicted to localize to the actin cortical patch and actin filament. Used to study Wiskott-Aldrich syndrome. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome and severe congenital neutropenia. Is expressed in hematopoietic system; leukocyte; neuromast; thrombocyte; and thymus. Orthologous to human WAS (WASP actin nucleation promoting factor).
Genome Resources: Alliance (1),  Gene:335158 (1),  Ensembl(GRCz11):ENSDARG00000026350 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (2 images) from Thisse et al., 2004 [MGC:64164]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3279 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hu3280 Point Mutation Unknown Unknown ENU
    sa1001 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16049 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34392 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-wasb N/A 2
    MO2-wasb N/A 1
    MO3-wasb N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH wasb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    thrombocytopenia Alliance Thrombocytopenia, X-linked 313900
    Thrombocytopenia, X-linked, intermittent 313900
    Wiskott-Aldrich syndrome Alliance Wiskott-Aldrich syndrome 301000
    Neutropenia, severe congenital, X-linked 300299
    DISEASE ASSOCIATED WITH wasb VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Wiskott-Aldrich syndrome wasbhu3280/hu3280 standard conditions Jones et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process leukocyte chemotaxis (more)
    Cellular Component actin cortical patch (more)
    Molecular Function actin binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000095 CRIB domain
    Domain IPR000697 WH1/EVH1 domain
    Domain IPR003124 WH2 domain
    Homologous_superfamily IPR011026 Wiscott-Aldrich syndrome protein, C-terminal
    Homologous_superfamily IPR011993 PH-like domain superfamily
    Family IPR027641 Wiskott-Aldrich syndrome protein
    Domain IPR033927 WASP family, EVH1 domain
    Homologous_superfamily IPR036936 CRIB domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA wasb-201 (1)    Ensembl 1735
    wasb-202 (1)    Ensembl 813
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM wasb No data available
    MARKER RELATIONSHIPS
    wasb Contained in: [BAC] CH211-233C3 (1)
    wasb Encodes: [EST] fk81c08
    [cDNA] MGC:64164 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199938 (1) 1748 bp
    Genomic GenBank:BX248384 (1) 155293 bp
    Select Tool
    Polypeptide UniProtKB:B0S5G8 (1) 479 aa
    Sequence Information (all 12)
    ORTHOLOGY for wasb ( Chr: 8 )
    CITATIONS (33)