Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-7098
Gene Name: Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b
Gene Symbol: wasb
Previous Names: was, wasp1 (1), wu:fk81c08
Nomenclature History
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (2 images) from Thisse et al., 2004 [MGC:64164]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  hematopoietic system, leukocyte, neuromast, thrombocyte (all 6) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 8 genotypes
Alleles: hu3279, hu3280, sa1001, sa16049
Knockdown reagents: MO1-wasb (1), MO2-wasb (1), MO3-wasb (1)
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Neutropenia, severe congenital, X-linked 300299
Thrombocytopenia, X-linked 313900
Thrombocytopenia, X-linked, intermittent 313900
Wiskott-Aldrich syndrome 301000
GENE ONTOLOGY
Ontology GO Term
Biological Process leukocyte chemotaxis (more)
Molecular Function actin binding (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000095 (1)
  • InterPro:IPR000697 (1)
  • InterPro:IPR003124 (1)
  • InterPro:IPR011026 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR027641 (1)
  • PROSITE:PS50108 (1)
  • PROSITE:PS50229 (1)
  • PROSITE:PS51082 (1)
  • Pfam:PF00568 (1)
  • Pfam:PF00786 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA wasb-001 (1) 1735
    wasb-002 (1) 813
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM wasb No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    wasb Contained in: [BAC] CH211-233C3 (1) (order this)
    wasb Encodes: [EST] fk81c08
    [cDNA] MGC:64164 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199938 (1) 1748 bp
    Genomic GenBank:BX248384 (1) 155293 bp
    Select Tool
    Polypeptide UniProtKB:B0S5G8 (1) 479 aa
    Sequence Clusters UniGene:23314 (1)
    Sequence Information (all 12)
    OTHER wasb GENE PAGES
  • Gene:335158 (1)
  • VEGA:OTTDARG00000020215 (1)
  • Ensembl(Zv9):ENSDARG00000026350 (1)
  • MAPPING INFORMATION
    Chr: 8 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish wasb 8  
    Human WAS X (Xp11.4-p11.21)
  • OMIM:300392
  • Gene:7454
  • Mouse Was X ( 3.65 cM)
  • MGI:105059
  • Gene:22376
  • CITATIONS (24)