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Gene

spry2

ID
ZDB-GENE-030131-7038
Name
sprouty RTK signaling antagonist 2
Symbol
spry2 Nomenclature History
Previous Names
  • wu:fk66h11
  • wu:fk93e11
  • zgc:110440
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Acts upstream of or within blood vessel development; dorsal/ventral pattern formation; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. Is expressed in several structures, including brain; forerunner cell group; hindbrain neural keel; midbrain hindbrain boundary neural keel; and sensory system. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Labalette et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With spry2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{?IgA nephropathy, susceptibility to, 3} 616818
Associated With spry2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR007875 Sprouty
Family IPR030780 Protein sprouty homologue 2
Domain Details Per Protein
Protein Length Protein sprouty homologue 2 Sprouty
UniProtKB:Q6ELZ9 301
UniProtKB:F1QU39 301
UniProtKB:Q4VBS7 301
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations