ZFIN ID: ZDB-GENE-030131-7023
Gene Name: capping actin protein of muscle Z-line subunit beta
Gene Symbol: capzb    Nomenclature History

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Previous Name: wu:fk65f06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Involved in muscle cell development and neural crest cell migration. Predicted to localize to F-actin capping protein complex. Is expressed in fin bud; head; pharyngeal arch; and somite. Used to study cleft palate. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta).
Genome Resources: Alliance (1),  Gene:335083 (1),  Ensembl(GRCz11):ENSDARG00000100252 (1)
GENE EXPRESSION
All Expression Data: Fig. 2 from Mukherjee et al., 2016
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1858bTg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH capzb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH capzb VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    cleft palate capzbhi1858bTg/hi1858bTg standard conditions Mukherjee et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process muscle cell development (more)
    Cellular Component cytoplasm (more)
    Molecular Function actin binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM capzb No data available
    MARKER RELATIONSHIPS
    capzb Encodes: [EST] fk65f06
    [cDNA] MGC:66149 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199935 (1)
    Genomic GenBank:CABZ01103986 (1) 5918 nt
    Polypeptide UniProtKB:Q7SXP1 (1) 273 aa
    Sequence Information (all 17)
    ORTHOLOGY for capzb ( Chr: 22 )
    CITATIONS (28)