capzb

ID

ZDB-GENE-030131-7023

Name

capping actin protein of muscle Z-line subunit beta

Symbol

capzb Nomenclature History

Previous Names

wu:fk65f06

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable actin filament binding activity. Acts upstream of or within muscle cell development and neural crest cell migration. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of F-actin capping protein complex. Is expressed in fin bud; head; pharyngeal arch; and somite. Used to study cleft palate. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Mukherjee et al., 2016

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With capzb Human Ortholog

No data available

Associated With capzb Via Experimental Models

Human Disease	Fish	Conditions	Citations
cleft palate	capzb^{hi1858bTg/hi1858bTg}	standard conditions	Mukherjee et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019771	F-actin capping protein, beta subunit, conserved site
Family	IPR001698	F-actin-capping protein subunit beta
Homologous_superfamily	IPR037282	F-actin-capping protein subunit alpha/beta
Homologous_superfamily	IPR042276	F-actin-capping protein subunit alpha/beta, domain 2
Homologous_superfamily	IPR043175	F-actin-capping protein subunit beta, N-terminal domain