Gene

orc1

ID

ZDB-GENE-030131-6960

Name

origin recognition complex, subunit 1

Symbol

orc1 Nomenclature History

Previous Names

orc1l
wu:fa11h08
zgc:55976 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have DNA replication origin binding activity. Involved in chordate embryonic development; regulation of growth; and response to yeast. Predicted to localize to nuclear chromosome, telomeric region and nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Is expressed in proliferative region and tail bud. Orthologous to human ORC1 (origin recognition complex subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55976 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With orc1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Meier-Gorlin syndrome 1	Alliance	Meier-Gorlin syndrome 1	224690

Associated With orc1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001025	Bromo adjacent homology (BAH) domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR015163	Cdc6, C-terminal
Domain	IPR041083	AAA lid domain
Family	IPR050311	Origin Recognition Complex 1/Cell Division Control Protein 6
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR043151	Bromo adjacent homology (BAH) domain superfamily

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	AAA lid domain	ATPase, AAA-type, core	Bromo adjacent homology (BAH) domain	Bromo adjacent homology (BAH) domain superfamily	Cdc6, C-terminal	Origin Recognition Complex 1/Cell Division Control Protein 6	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q7ZYW6 InterPro	910
UniProtKB:F1QLF9 InterPro	912
UniProtKB:A0A8M9PM45 InterPro	873

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	orc1-202 (1) Ensembl	Ensembl	3,328 nt	Select Tool ZFIN BLAST
mRNA	orc1-204 (1) Ensembl	Ensembl	3,322 nt	Select Tool ZFIN BLAST
mRNA	orc1-205 (1) Ensembl	Ensembl	6,894 nt	Select Tool ZFIN BLAST
ncRNA	orc1-002 (1) Ensembl	Ensembl	395 nt	Select Tool ZFIN BLAST
ncRNA	orc1-003 (1) Ensembl	Ensembl	900 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations