ZFIN ID: ZDB-GENE-030131-6872
Gene Name: MDM4 regulator of p53
Gene Symbol: mdm4    Nomenclature History

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Previous Names: wu:fa09h09, wu:fi33d10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity. Predicted to be involved in negative regulation of apoptotic process and negative regulation of cell cycle arrest. Predicted to localize to nucleus. Orthologous to human MDM4 (MDM4 regulator of p53).
Genome Resources: Alliance (1),  Gene:334932 (1),  Ensembl(GRCz11):ENSDARG00000057513 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:113995]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1700 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6207 Point Mutation Unknown Premature Stop ENU
    sa10933 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38838 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45427 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sq29 Small Deletion Exon 3 Premature Stop ZINC_FINGER_NUCLEASE
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sq30 Small Deletion Exon 3 Premature Stop ZINC_FINGER_NUCLEASE
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sq31 Indel Exon 3 Premature Stop ZINC_FINGER_NUCLEASE
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mdm4 N/A 1
    TALEN1-mdm4
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mdm4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Bone marrow failure syndrome 6 618849
    DISEASE ASSOCIATED WITH mdm4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of apoptotic process (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mdm4-201 (1)    Ensembl 3200
    mdm4-202 (1)    Ensembl 3148
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mdm4 No data available
    MARKER RELATIONSHIPS
    mdm4 Contained in: [BAC] CH211-195N8 (1), DKEY-25F1 (1) (order this)
    mdm4 Encodes: [EST] fa09h09, fi33d10 (1)
    [cDNA] MGC:55999 (1), MGC:113995 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212732 (1) 3167 nt
    Genomic GenBank:BX545854 (1) 190179 nt
    Select Tool
    Polypeptide UniProtKB:F1QD25 (1) 496 aa
    Sequence Information (all 28)
    ORTHOLOGY for mdm4 ( Chr: 11 )
    CITATIONS (33)