ZFIN ID: ZDB-GENE-030131-684
Gene Name: tafazzin
Gene Symbol: taz    Nomenclature History

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Previous Names: wu:fb39f12, zgc:91803

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have O-acyltransferase activity. Involved in heart looping and positive regulation of heart contraction. Predicted to localize to integral component of mitochondrial outer membrane. Used to study Barth syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Is expressed in endoderm; head; immature eye; pericardial region; and post-vent region. Orthologous to human TAZ (tafazzin).
Genome Resources: Alliance (1),  Gene:321965 (1),  Ensembl(GRCz11):ENSDARG00000041421 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6909625]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa44993 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-taz N/A 1
    MO2-taz N/A 1
    MO3-taz N/A 1
    MO4-taz N/A 1
    DISEASE ASSOCIATED WITH taz HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Barth syndrome Alliance Barth syndrome 302060
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart development (more)
    Cellular Component integral component of mitochondrial outer membrane (more)
    Molecular Function transferase activity, transferring acyl groups (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript taz-202 (1)    Ensembl 827
    taz-208 (1)    Ensembl 694
    mRNA taz-203 (1)    Ensembl 495
    taz-205 (1)    Ensembl 1824
    ncRNA taz-002 (1)    Ensembl 918
    taz-004 (1)    Ensembl 1158
    taz-005 (1)    Ensembl 908
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM taz No data available
    MARKER RELATIONSHIPS
    taz Contained in: [BAC] CH211-117K14 (1)
    taz Encodes: [EST] fb39f12, IMAGE:6909625 (1)
    [cDNA] MGC:91803 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001814 (1) 1759 nt
    Genomic GenBank:CR354596 (1) 172749 nt
    Select Tool
    Polypeptide UniProtKB:F1QCP6 (1) 262 aa
    Sequence Information (all 21)
    ORTHOLOGY for taz ( Chr: 23 )
    CITATIONS (28)