ZFIN ID: ZDB-GENE-030131-6795
Gene Name: phosphatidylinositol binding clathrin assembly protein b
Gene Symbol: picalmb    Nomenclature History

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Previous Names: picalm, picalml, fa01d03, wu:fa01d03 (1), wu:fa05d03, wu:fb69g01, wu:fe17e02, zgc:91993

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle budding from presynaptic endocytic zone membrane. Predicted to localize to clathrin-coated pit; cytoplasmic vesicle; and extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein).
Genome Resources: Alliance (1),  Gene:445286 (1),  Ensembl(GRCz11):ENSDARG00000014137 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:91993]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:6911564]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019197Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la019198Tg Transgenic Insertion Unknown Unknown DNA
    sa2794 Point Mutation Unknown Splice Site ENU
    sa9760 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH picalmb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
    DISEASE ASSOCIATED WITH picalmb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process clathrin coat assembly (more)
    Cellular Component clathrin-coated vesicle (more)
    Molecular Function 1-phosphatidylinositol binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA picalmb-203 (1)    Ensembl 1634
    ncRNA picalmb-002 (1) 627
    picalmb-003 (1) 537
    picalmb-004 (1) 161
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM picalmb No data available
    MARKER RELATIONSHIPS
    picalmb Contained in: [BAC] CH211-190H2 (1), CH211-193I17 (1), CH211-229D2 (1), DKEY-4P15 (1) (order this)
    picalmb Encodes: [EST] fa01d03, fa05d03, fb69g01 (1), fe17e02 (1), IMAGE:6911564 (1)
    [cDNA] MGC:91993 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003741 (1) 3495 nt
    Genomic GenBank:CR626889 (1) 205513 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B0R0Z7 (1) 667 aa
    Sequence Information (all 55)
    ORTHOLOGY for picalmb ( Chr: 15 )
    CITATIONS (26)