Gene

nfkb2

ID
ZDB-GENE-030131-6701
Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Symbol
nfkb2 Nomenclature History
Previous Names
  • p100/p52 (1)
  • p100 (1)
  • wu:fa03b02 (1)
  • zgc:136693
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in angiogenesis and cholesterol homeostasis. Predicted to localize to I-kappaB/NF-kappaB complex; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nfkb2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
common variable immunodeficiency Alliance Immunodeficiency, common variable, 10 615577
Associated With nfkb2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030492 Rel homology domain, conserved site
Domain IPR000488 Death domain
Domain IPR002909 IPT domain
Domain IPR011539 Rel homology domain (RHD), DNA-binding domain
Domain IPR032397 Rel homology dimerisation domain
Domain IPR033926 NFkappaB IPT domain
Family IPR000451 NF-kappa-B/Dorsal
Family IPR030497 Nuclear factor NF-kappa-B, p100 subunit
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Homologous_superfamily IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain superfamily Death domain Death-like domain superfamily Immunoglobulin E-set Immunoglobulin-like fold IPT domain NF-kappa-B/Dorsal NFkappaB IPT domain Nuclear factor NF-kappa-B, p100 subunit p53-like transcription factor, DNA-binding Rel homology dimerisation domain Rel homology domain, conserved site Rel homology domain (RHD), DNA-binding domain Rel homology domain (RHD), DNA-binding domain superfamily
UniProtKB:Q4PLU6 241
UniProtKB:A0A2R8RJY5 863
UniProtKB:Q0II00 902
UniProtKB:Q6K198 902
UniProtKB:B8A4B4 241
UniProtKB:Q4PLU7 247
UniProtKB:F1R3P4 100
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations