ZFIN ID: ZDB-GENE-030131-6577
Gene Name: prohibitin
Gene Symbol: phb    Nomenclature History

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Previous Names: fa18f07, fb09f05, sr:nyz128, wu:fa18f07 (1), wu:fb09f05 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to localize to mitochondrial inner membrane. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; midbrain; and musculature system. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB (prohibitin).
Genome Resources: Alliance (1),  Gene:321346 (1),  Ensembl(GRCz11):ENSDARG00000057414 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:77919]
  6 figures (14 images) from Thisse et al., 2004 [IMAGE:7161082]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa38378 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH phb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    breast cancer Alliance {Breast cancer, susceptibility to} 114480
    DISEASE ASSOCIATED WITH phb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component membrane (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA phb-201 (1)    Ensembl 1763
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM phb No data available
    MARKER RELATIONSHIPS
    phb Contained in: [BAC] CH211-152F6 (1)
    phb Encodes: [EST] fa18f07, fb09f05 (1), IMAGE:7161082 (1), nyz128
    [cDNA] MGC:66059 (1), MGC:77919 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201297 (1) 1731 nt
    Genomic GenBank:BX936308 (1) 110020 nt
    Select Tool
    Polypeptide UniProtKB:Q7T1D8 (1) 271 aa
    Sequence Information (all 21)
    ORTHOLOGY for phb ( Chr: 3 )
    CITATIONS (30)