Gene
ubr5
- ID
- ZDB-GENE-030131-6559
- Name
- ubiquitin protein ligase E3 component n-recognin 5
- Symbol
- ubr5 Nomenclature History
- Previous Names
-
- edd1 (1)
- wu:fa16c12
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have several functions, including ubiquitin binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of histone H2A K63-linked ubiquitination; protein polyubiquitination; and regulation of double-strand break repair. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000569 | HECT domain |
| Domain | IPR002004 | Polyadenylate-binding protein/Hyperplastic disc protein |
| Domain | IPR003126 | Zinc finger, UBR-type |
| Domain | IPR024725 | E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain |
| Domain | IPR047503 | E3 ubiquitin-protein ligase UBR5, UBR-box |
| Homologous_superfamily | IPR009091 | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II |
| Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
| Homologous_superfamily | IPR036053 | PABC (PABP) domain |
Domain Details Per Protein
| Protein | Length | E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain | E3 ubiquitin-protein ligase UBR5, UBR-box | HECT domain | HECT, E3 ligase catalytic domain | PABC (PABP) domain | Polyadenylate-binding protein/Hyperplastic disc protein | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II | Zinc finger, UBR-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P7S4
|
2828 | ||||||||
|
UniProtKB:A0A8M1NV16
|
2794 | ||||||||
|
UniProtKB:A0A8M9PJ96
|
2833 | ||||||||
|
UniProtKB:A0A8M2B4T2
|
2816 | ||||||||
|
UniProtKB:A0A8M9NZ45
|
2832 | ||||||||
|
UniProtKB:A0A8M9PM86
|
2822 | ||||||||
|
UniProtKB:A0A8M2B598
|
2822 | ||||||||
|
UniProtKB:A0A8M9PJA4
|
2793 | ||||||||
|
UniProtKB:A0A8M9PCY7
|
2827 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available