Community Action Needed: Please respond to the NIH RFI
Gene

ppp1cbl

ID
ZDB-GENE-030131-6529
Name
protein phosphatase 1, catalytic subunit, beta isoform, like
Symbol
ppp1cbl Nomenclature History
Previous Names
  • PPP1CBb (1)
  • ppp1cbb (1)
  • wu:fa14b10
  • zgc:64169
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Enables protein heterodimerization activity. Acts upstream of or within convergent extension involved in axis elongation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Jayashankar et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ppp1cbl Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Noonan syndrome-like disorder with loose anagen hair 2 Alliance Noonan syndrome-like disorder with loose anagen hair 2 617506
Associated With ppp1cbl Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
Domain IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Domain IPR031675 Serine-threonine protein phosphatase, N-terminal
Homologous_superfamily IPR029052 Metallo-dependent phosphatase-like
Domain Details Per Protein
Protein Length Calcineurin-like phosphoesterase domain, ApaH type Metallo-dependent phosphatase-like Serine-threonine protein phosphatase, N-terminal Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
UniProtKB:Q7T313 281
UniProtKB:A0A0R4IA80 231
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations