ZFIN ID: ZDB-GENE-030131-647
Gene Name: phosphoglycerate dehydrogenase
Gene Symbol: phgdh    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: fb38f06, wu:fb38f06, zgc:65956 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have phosphoglycerate dehydrogenase activity. Predicted to be involved in cellular amino acid metabolic process. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase).
Genome Resources: Alliance (1),  Gene:321928 (1),  Ensembl(GRCz11):ENSDARG00000001873 (2)
GENE EXPRESSION
All Expression Data: Fig. 5 from Ferg et al., 2007
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Blastula:30%-epiboly (4.66h-5.25h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029622Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1248 Point Mutation Unknown Premature Stop ENU
    sa16263 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH phgdh HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neu-Laxova syndrome 1 Alliance Neu-Laxova syndrome 1 256520
    PHGDH deficiency Alliance Phosphoglycerate dehydrogenase deficiency 601815
    DISEASE ASSOCIATED WITH phgdh VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular amino acid biosynthetic process (more)
    Cellular Component cellular_component (more)
    Molecular Function NAD binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA phgdh-201 (1)    Ensembl 2374
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM phgdh No data available
    MARKER RELATIONSHIPS
    phgdh Contained in: [BAC] DKEYP-13F6 (1)
    phgdh Encodes: [EST] fb38f06
    [cDNA] MGC:65956 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199577 (1) 1866 nt
    Genomic GenBank:BX321905 (1) 164006 nt
    Select Tool
    Polypeptide UniProtKB:F1QEY8 (1) 528 aa
    Sequence Information (all 15)
    ORTHOLOGY for phgdh ( Chr: 9 )
    CITATIONS (31)