ZFIN ID: ZDB-GENE-030131-647
Gene Name: phosphoglycerate dehydrogenase
Gene Symbol: phgdh
Sequence Ontology ID : SO:0000704

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Previous Names: fb38f06, wu:fb38f06, zgc:65956 (1)

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(Including Attributions)
Location: Chr: 9 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have phosphoglycerate dehydrogenase activity; predicted to be involved in L-serine biosynthetic process and oxidation-reduction process; orthologous to human PHGDH (phosphoglycerate  ...
GENE EXPRESSION
All Expression Data: Fig. 5 from Ferg et al., 2007
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Blastula:30%-epiboly (4.66h-5.25h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029622Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1248 Point Mutation Unknown Premature Stop ENU
    sa16263 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH phgdh HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Neu-Laxova syndrome 1 Neu-Laxova syndrome 1 256520
    PHGDH deficiency Phosphoglycerate dehydrogenase deficiency 601815
    DISEASE ASSOCIATED WITH phgdh VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular amino acid biosynthetic process (more)
    Cellular Component cellular_component (more)
    Molecular Function NAD binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006139 (1)
  • InterPro:IPR006140 (1)
  • InterPro:IPR006236 (1)
  • InterPro:IPR029009 (1)
  • InterPro:IPR029752 (1)
  • InterPro:IPR036291 (1)
  • PROSITE:PS00065 (1)
  • Pfam:PF00389 (1)
  • Pfam:PF02826 (1)
  • EC:1.1.1.95 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA phgdh-201 (1) 2374
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM phgdh No data available
    MARKER RELATIONSHIPS
    phgdhContained in: [BAC] DKEYP-13F6 (1)
    phgdhEncodes: [EST] fb38f06
    [cDNA] MGC:65956 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199577 (1) 1866bp
    Genomic GenBank:BX321905 (1) 164006bp
    Select Tool
    Polypeptide UniProtKB:F1QEY8 (1) 528aa
    Sequence Clusters UniGene:28276 (1)
    Sequence Information (all 16)
    OTHER phgdh GENE PAGES
  • Alliance (1)
  • Gene:321928 (1)
  • VEGA:OTTDARG00000021695 (1)
  • Ensembl(GRCz11):ENSDARG00000001873 (2)
  • ORTHOLOGY for phgdh (Chr: 9)
    CITATIONS (29)