ZFIN ID: ZDB-GENE-030131-6456
Gene Name: PHD finger protein 21Ab
Gene Symbol: phf21ab    Nomenclature History

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Previous Names: phf21a, fj98d03, wu:fj98d03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have chromatin binding activity. Involved in face development. Predicted to localize to the histone deacetylase complex. Is expressed in head; nervous system; optic cup; otic vesicle; and pectoral fin. Orthologous to human PHF21A (PHD finger protein 21A).
Genome Resources: Alliance (1),  Gene:565544 (1),  Ensembl(GRCz11):ENSDARG00000021378 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa3290 Point Mutation Unknown Missense, Premature Stop ENU
sa18275 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-phf21ab
    1
    CRISPR2-phf21ab
    1
    MO1-phf21ab N/A 1
    MO2-phf21ab N/A 1
    MO3-phf21ab N/A 1
    DISEASE ASSOCIATED WITH phf21ab HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodevelopmental disorder with macrocephaly and seizures 618725
    DISEASE ASSOCIATED WITH phf21ab VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process face development (more)
    Cellular Component histone deacetylase complex (more)
    Molecular Function DNA binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001965 Zinc finger, PHD-type
    Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
    Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
    Conserved_site IPR017956 AT hook, DNA-binding motif
    Conserved_site IPR019786 Zinc finger, PHD-type, conserved site
    Domain IPR019787 Zinc finger, PHD-finger
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA phf21ab-201 (1)    Ensembl 3367
    phf21ab-203 (1)    Ensembl 881
    phf21ab-204 (1)    Ensembl 260
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM phf21ab No data available
    MARKER RELATIONSHIPS
    phf21ab Contained in: [BAC] CH211-95A17 (1), CH211-286C4
    phf21ab Encodes: [EST] fj98d03
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005174280 (1) 3282 bp
    Genomic GenBank:BX088562 (1) 138646 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8RUQ1 (1) 828 aa
    Sequence Information (all 42)
    ORTHOLOGY for phf21ab ( Chr: 25 )
    CITATIONS (21)