ZFIN ID: ZDB-GENE-030131-6420
Gene Name: X-ray repair complementing defective repair in Chinese hamster cells 6
Gene Symbol: xrcc6    Nomenclature History

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Previous Names: g22p1, Ku autoantigen, Ku70, wu:fi87b06, zgc:64131

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to contribute to double-stranded DNA binding activity. Involved in response to ionizing radiation. Predicted to localize to Ku70:Ku80 complex and nuclear chromosome, telomeric region. Is expressed in head; nervous system; neural keel; post-vent region; and presumptive neural retina. Orthologous to human XRCC6 (X-ray repair cross complementing 6).
Genome Resources: Alliance (1),  Gene:334488 (1),  Ensembl(GRCz11):ENSDARG00000071551 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2485 Point Mutation Exon 10 Premature Stop
hu2487 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-xrcc6
1
MO1-xrcc6 N/A 1
MO2-xrcc6 N/A 3
PHENOTYPE
Data: Fig. 4 from Feitsma et al., 2008
Observed in:
DISEASE ASSOCIATED WITH xrcc6 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH xrcc6 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to ionizing radiation (more)
Cellular Component Ku70:Ku80 complex (more)
Molecular Function damaged DNA binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA xrcc6-201 (1)    Ensembl 2228
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM xrcc6 No data available
MARKER RELATIONSHIPS
xrcc6 Contained in: [BAC] CH211-120D1 (1), CH211-167D24 (1)
xrcc6 Encodes: [EST] fi87b06, IMAGE:7139458 (1)
[cDNA] MGC:64131 (1), MGC:174531 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_199904 (1) 2167 nt
Genomic GenBank:CU914479 (1) 160074 nt
Select Tool
Polypeptide UniProtKB:A8KC26 (1) 610 aa
Sequence Information (all 25)
ORTHOLOGY for xrcc6 ( Chr: 12 )
CITATIONS (38)