ZFIN ID: ZDB-GENE-030131-638
Gene Name: glutamyl-prolyl-tRNA synthetase 1
Gene Symbol: eprs1    Nomenclature History

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Previous Names: eprs, wu:fb06c03, wu:fb38d08, wu:ft34d10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to localize to aminoacyl-tRNA synthetase multienzyme complex and cytoplasm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1).
Genome Resources: Alliance (1),  Gene:562037 (1),  Ensembl(GRCz11):ENSDARG00000060494 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7145319]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23149 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36487 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44876 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH eprs1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Leukodystrophy, hypomyelinating, 15 617951
    DISEASE ASSOCIATED WITH eprs1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process glutamyl-tRNA aminoacylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function aminoacyl-tRNA ligase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eprs-202 (1)    Ensembl 5178
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eprs1 No data available
    MARKER RELATIONSHIPS
    eprs1 Contained in: [BAC] DKEY-229E3 (1) (order this)
    eprs1 Encodes: [EST] fb06c03, fb38d08, ft34d10, IMAGE:7145319 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001204248 (1) 4917 nt
    Genomic GenBank:BX469926 (1) 242408 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QP23 (1) 1683 aa
    Sequence Information (all 23)
    ORTHOLOGY for eprs1 ( Chr: 17 )
    CITATIONS (23)