Gene

eprs1

ID
ZDB-GENE-030131-638
Name
glutamyl-prolyl-tRNA synthetase 1
Symbol
eprs1 Nomenclature History
Previous Names
  • eprs
  • wu:fb06c03
  • wu:fb38d08
  • wu:ft34d10
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to act upstream of or within glutamyl-tRNA aminoacylation. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With eprs1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leukodystrophy, hypomyelinating, 15 617951
Associated With eprs1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Domain IPR000738 WHEP-TRS domain
Domain IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Domain IPR004046 Glutathione S-transferase, C-terminal
Domain IPR004154 Anticodon-binding
Domain IPR006195 Aminoacyl-tRNA synthetase, class II
Domain IPR010987 Glutathione S-transferase, C-terminal-like
Domain IPR016061 Proline-tRNA ligase, class II, C-terminal
Domain IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
Domain IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
Domain IPR033721 Prolyl-tRNA synthetase, catalytic domain
Family IPR000924 Glutamyl/glutaminyl-tRNA synthetase
Family IPR002316 Proline-tRNA ligase, class IIa
Family IPR004499 Proline-tRNA ligase, class IIa, archaeal-type
Family IPR004526 Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic
Homologous_superfamily IPR009068 S15/NS1, RNA-binding
Homologous_superfamily IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily IPR017449 Prolyl-tRNA synthetase, class II
Homologous_superfamily IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, N-terminal
Homologous_superfamily IPR020061 Glutamine-tRNA ligase, alpha-bundle domain superfamily
Homologous_superfamily IPR036282 Glutathione S-transferase, C-terminal domain superfamily
Homologous_superfamily IPR036621 Anticodon-binding domain superfamily
Homologous_superfamily IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class I, conserved site Aminoacyl-tRNA synthetase, class II Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) Anticodon-binding Anticodon-binding domain superfamily Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) Glutamine-tRNA ligase, alpha-bundle domain superfamily Glutamyl/glutaminyl-tRNA synthetase Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic Glutathione S-transferase, C-terminal Glutathione S-transferase, C-terminal domain superfamily Glutathione S-transferase, C-terminal-like Proline-tRNA ligase, class IIa Proline-tRNA ligase, class IIa, archaeal-type Proline-tRNA ligase, class II, C-terminal Prolyl-tRNA synthetase, catalytic domain Prolyl-tRNA synthetase, class II Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily Ribosomal protein L25/Gln-tRNA synthetase, N-terminal Rossmann-like alpha/beta/alpha sandwich fold S15/NS1, RNA-binding WHEP-TRS domain
UniProtKB:A8WG07 476
UniProtKB:F1QP23 1683
UniProtKB:X1WGZ7 1598
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations