ZFIN ID: ZDB-GENE-030131-6363
Gene Name: adenylosuccinate lyase
Gene Symbol: adsl    Nomenclature History

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Previous Names: fi60b04, wu:fi60b04, zgc:56061 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Predicted to be involved in 'de novo' AMP biosynthetic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. Orthologous to human ADSL (adenylosuccinate lyase).
Genome Resources: Alliance (1),  Gene:334431 (1),  Ensembl(GRCz11):ENSDARG00000017049 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Gastrula:75%-epiboly (8.0h-9.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024035Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH adsl HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    adenylosuccinase lyase deficiency Alliance Adenylosuccinase deficiency 103050
    DISEASE ASSOCIATED WITH adsl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process 'de novo' AMP biosynthetic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA adsl-201 (1)    Ensembl 1685
    adsl-202 (1)    Ensembl 806
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adsl No data available
    MARKER RELATIONSHIPS
    adsl Contained in: [BAC] DKEY-110G7 (1) (order this)
    adsl Encodes: [cDNA] MGC:56061 (1), MGC:86656 (1), MGC:174389 (1), MGC:191389 (1)
    adsl Has Artifact: [EST] fi60b04
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199899 (1) 1607 nt
    Genomic GenBank:CR812472 (1) 194804 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QND3 (1) 488 aa
    Sequence Information (all 31)
    ORTHOLOGY for adsl ( Chr: 3 )
    CITATIONS (29)