Community Action Needed: Please respond to the NIH RFI
Gene

brf1a

ID
ZDB-GENE-030131-6334
Name
BRF1 RNA polymerase III transcription initiation factor subunit a
Symbol
brf1a Nomenclature History
Previous Names
  • brf1
  • wu:fi47f03
  • zgc:55543 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable RNA polymerase III general transcription initiation factor activity and RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Acts upstream of or within neutrophil differentiation. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Is expressed in several structures, including head; midbrain; notochord; pectoral fin musculature; and polster. Human ortholog(s) of this gene implicated in cerebellofaciodental syndrome. Orthologous to human BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Bielczyk-MaczyƄska et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With brf1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cerebellofaciodental syndrome Alliance Cerebellofaciodental syndrome 616202
Associated With brf1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011665 Brf1, TBP-binding domain
Domain IPR013137 Zinc finger, TFIIB-type
Domain IPR013150 Transcription factor TFIIB, cyclin-like domain
Domain IPR013763 Cyclin-like
Family IPR000812 Transcription factor TFIIB
Family IPR029529 Transcription factor IIIB subunit Brf1
Homologous_superfamily IPR036915 Cyclin-like superfamily
Domain Details Per Protein
Protein Length Brf1, TBP-binding domain Cyclin-like Cyclin-like superfamily Transcription factor IIIB subunit Brf1 Transcription factor TFIIB Transcription factor TFIIB, cyclin-like domain Zinc finger, TFIIB-type
UniProtKB:Q802Z8 661
UniProtKB:B8A4L9 86
UniProtKB:F1R9S3 661
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations