ZFIN ID: ZDB-GENE-030131-6325
Gene Name: isoleucyl-tRNA synthetase 1
Gene Symbol: iars1    Nomenclature History

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Previous Names: iars, fi46h05, wu:fi46h05, zgc:63790 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have isoleucine-tRNA ligase activity. Involved in regulation of sprouting angiogenesis. Is expressed in brain; head; neural rod; and somite. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1).
Genome Resources: Alliance (1),  Gene:334393 (1),  Ensembl(GRCz11):ENSDARG00000007955 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21826 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27708 Point Mutation Unknown Splice Site ENU
    sa41755 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • y68 Point Mutation Unknown Missense ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-iars1 N/A 1
    MO2-iars1 N/A 1
    MO3-iars1 N/A 1
    DISEASE ASSOCIATED WITH iars1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Growth retardation, impaired intellectual development, hypotonia, and hepatopathy 617093
    DISEASE ASSOCIATED WITH iars1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of sprouting angiogenesis (more)
    Molecular Function aminoacyl-tRNA editing activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM iars1 No data available
    MARKER RELATIONSHIPS
    iars1 Contained in: [BAC] DKEY-46N5 (1) (order this)
    iars1 Encodes: [EST] fi46h05
    [cDNA] MGC:63790 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199896 (1) 3972 nt
    Genomic GenBank:BX890614 115990 nt
    Select Tool
    Polypeptide UniProtKB:Q6PGU7 (1) 1271 aa
    Sequence Information (all 26)
    ORTHOLOGY for iars1 ( Chr: 11 )
    CITATIONS (25)