Gene

iars1

ID
ZDB-GENE-030131-6325
Name
isoleucyl-tRNA synthetase 1
Symbol
iars1 Nomenclature History
Previous Names
  • iars
  • fi46h05
  • wu:fi46h05
  • zgc:63790 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have isoleucine-tRNA ligase activity. Involved in regulation of sprouting angiogenesis. Is expressed in brain; head; neural rod; and somite. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With iars1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Growth retardation, impaired intellectual development, hypotonia, and hepatopathy 617093
Associated With iars1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Domain IPR002300 Aminoacyl-tRNA synthetase, class Ia
Domain IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
Domain IPR033709 Isoleucyl tRNA synthetase type 2, anticodon-binding domain
Family IPR002301 Isoleucine-tRNA ligase
Family IPR023586 Isoleucine-tRNA ligase, type 2
Homologous_superfamily IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Homologous_superfamily IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ia Aminoacyl-tRNA synthetase, class Ia, anticodon-binding Aminoacyl-tRNA synthetase, class I, conserved site Isoleucine-tRNA ligase Isoleucine-tRNA ligase, type 2 Isoleucyl tRNA synthetase type 2, anticodon-binding domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding Rossmann-like alpha/beta/alpha sandwich fold Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
UniProtKB:Q6PGU7 1271
UniProtKB:A8E7S5 599
UniProtKB:F1QSY7 1270
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations