Gene

chd8

ID
ZDB-GENE-030131-6320
Name
chromodomain helicase DNA binding protein 8
Symbol
chd8 Nomenclature History
Previous Names
  • si:ch211-10e2.6 (1)
  • wu:fi45h08
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable several functions, including ATP binding activity; beta-catenin binding activity; and p53 binding activity. Involved in forebrain development; midbrain development; and negative regulation of neural precursor cell proliferation. Acts upstream of or within brain development and enteric nervous system development. Predicted to be located in nucleus. Predicted to be part of MLL1 complex. Is expressed in blastomere; brain; gut; head; and spinal cord. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human CHD8 (chromodomain helicase DNA binding protein 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Bernier et al., 2014
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With chd8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Autism, susceptibility to, 18} 615032
Associated With chd8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000330 SNF2-related domain
Domain IPR000953 Chromo/chromo shadow domain
Domain IPR001650 Helicase, C-terminal
Domain IPR006576 BRK domain
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR023780 Chromo domain
Family IPR034724 Chromodomain-helicase-DNA-binding protein 8
Homologous_superfamily IPR016197 Chromo-like domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR037259 BRK domain superfamily
Homologous_superfamily IPR038718 SNF2-like, N-terminal domain superfamily
Domain Details Per Protein
Protein Length BRK domain BRK domain superfamily Chromo/chromo shadow domain Chromo domain Chromodomain-helicase-DNA-binding protein 8 Chromo-like domain superfamily Helicase, C-terminal Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase SNF2-like, N-terminal domain superfamily SNF2-related domain
UniProtKB:B0R0I6 2511
UniProtKB:F1QW70 2231
UniProtKB:A0A2R8PZ65 2097
UniProtKB:E7FH24 2555
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations