Gene

brf1b

ID
ZDB-GENE-030131-6248
Name
BRF1 RNA polymerase III transcription initiation factor subunit b
Symbol
brf1b Nomenclature History
Previous Names
  • fi40c10
  • wu:fi40c10
  • zgc:63497
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable RNA polymerase III general transcription initiation factor activity and RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Acts upstream of or within cerebellum development and thrombocyte differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Is expressed in head. Human ortholog(s) of this gene implicated in cerebellofaciodental syndrome. Orthologous to human BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Borck et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With brf1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cerebellofaciodental syndrome Alliance Cerebellofaciodental syndrome 616202
Associated With brf1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011665 Brf1, TBP-binding domain
Domain IPR013137 Zinc finger, TFIIB-type
Domain IPR013150 Transcription factor TFIIB, cyclin-like domain
Domain IPR013763 Cyclin-like
Family IPR000812 Transcription factor TFIIB
Family IPR029529 Transcription factor IIIB subunit Brf1
Homologous_superfamily IPR036915 Cyclin-like superfamily
Domain Details Per Protein
Protein Length Brf1, TBP-binding domain Cyclin-like Cyclin-like superfamily Transcription factor IIIB subunit Brf1 Transcription factor TFIIB Transcription factor TFIIB, cyclin-like domain Zinc finger, TFIIB-type
UniProtKB:Q1LXP0 606
UniProtKB:A0A2R8QF19 674
UniProtKB:Q6P9Z3 693
UniProtKB:Q5TZ89 693
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations