ZFIN ID: ZDB-GENE-030131-6210
Gene Name: Rho guanine nucleotide exchange factor (GEF) 10
Gene Symbol: arhgef10    Nomenclature History

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Previous Name: wu:fi38h08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have Rho guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization and positive regulation of stress fiber assembly. Predicted to localize to the centrosome and cytosol. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10).
Genome Resources: Alliance (1),  Gene:334278 (1),  Ensembl(GRCz11):ENSDARG00000077788 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23085 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28858 Point Mutation Unknown Splice Site ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH arhgef10 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Slowed nerve conduction velocity, AD 608236
    DISEASE ASSOCIATED WITH arhgef10 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mitotic spindle assembly (more)
    Cellular Component centrosome (more)
    Molecular Function guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000219 Dbl homology (DH) domain
    Family IPR030632 Rho guanine nucleotide exchange factor 10
    Family IPR039919 Rho guanine nucleotide exchange factor 10/17
    Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
    Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arhgef10-202 (1)    Ensembl 4004
    ncRNA arhgef10-002 (1)    Ensembl 780
    arhgef10-003 (1)    Ensembl 296
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arhgef10 No data available
    MARKER RELATIONSHIPS
    arhgef10 Contained in: [BAC] CH73-186D22, CH211-266A16
    arhgef10 Encodes: [EST] fi38h08, wz11627
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009293079 (1)
    Genomic GenBank:BX005351 (1) 167042 nt
    Select Tool
    Polypeptide UniProtKB:E7F3Z6 (1) 1239 aa
    Sequence Information (all 23)
    ORTHOLOGY for arhgef10 ( Chr: 17 )
    CITATIONS (15)