Gene

arhgef10

ID

ZDB-GENE-030131-6210

Name

Rho guanine nucleotide exchange factor (GEF) 10

Symbol

arhgef10 Nomenclature History

Previous Names

wu:fi38h08

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have Rho guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization; mitotic spindle assembly; and positive regulation of stress fiber assembly. Predicted to localize to centrosome. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Slowed nerve conduction velocity, AD	608236

Associated With arhgef10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Family	IPR030632	Rho guanine nucleotide exchange factor 10
Family	IPR039919	Rho guanine nucleotide exchange factor 10/17
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily

Domain Details Per Protein

Protein	Length	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Rho guanine nucleotide exchange factor 10	Rho guanine nucleotide exchange factor 10/17	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:E7F3Z6 InterPro	1239

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	arhgef10-202 (1) Ensembl	4004 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	arhgef10-002 (1) Ensembl	780 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	arhgef10-003 (1) Ensembl	296 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations