ZFIN ID: ZDB-GENE-030131-6206
Gene Name: myosin heavy chain 4
Gene Symbol: myhc4    Nomenclature History

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Previous Names: fi38g05, fmyhc2.2 (1), wu:fi17f08, wu:fi38g05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in distal arthrogryposis and multiple pterygium syndrome. Is expressed in fin; musculature system; segmental plate; and trunk. Orthologous to several human genes including MYH1 (myosin heavy chain 1).
Genome Resources: Alliance (1),  Gene:334274 (1),  Ensembl(GRCz11):ENSDARG00000035438 (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH myhc4 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH myhc4 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component myosin complex (more)
Molecular Function actin binding (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA myhc4-202 (1)    Ensembl 416
myhc4-203 (1)    Ensembl 5981
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM myhc4 No data available
MARKER RELATIONSHIPS
myhc4 Contained in: [BAC] CH211-251M3 (1)
myhc4 Encodes: [EST] fi17f08, fi38g05
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001020485 (1) 5913 bp
Genomic GenBank:BX511237 (1) 52527 bp
Select Tool
Polypeptide UniProtKB:A2BGX6 (1) 1935 aa
Sequence Information (all 18)
ORTHOLOGY for myhc4 ( Chr: 5 )
CITATIONS (40)