ZFIN ID: ZDB-GENE-030131-6202
Gene Name: acylglycerol kinase
Gene Symbol: agk    Nomenclature History

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Previous Names: fi38e09, mulk, wu:fi38e09, zgc:55462 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have acylglycerol kinase activity; ceramide kinase activity; and diacylglycerol kinase activity. Predicted to be involved in ceramide biosynthetic process; phosphorylation; and protein insertion into mitochondrial inner membrane. Predicted to localize to TIM22 mitochondrial import inner membrane insertion complex; integral component of mitochondrial inner membrane; and mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in Sengers syndrome and cataract 38. Orthologous to human AGK (acylglycerol kinase).
Genome Resources: Alliance (1),  Gene:334270 (1),  Ensembl(GRCz11):ENSDARG00000009837 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55462]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9625 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32202 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH agk HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cataract 38 Alliance Cataract 38, autosomal recessive 614691
    Sengers syndrome Alliance Sengers syndrome 212350
    DISEASE ASSOCIATED WITH agk VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA agk-201 (1)    Ensembl 2480
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM agk No data available
    MARKER RELATIONSHIPS
    agk Contained in: [BAC] CH211-238N5 (1)
    agk Encodes: [EST] fi38e09
    [cDNA] MGC:55462 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199880 (1) 2496 nt
    Genomic GenBank:BX470166 (1) 117241 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8RHM6 (1) 422 aa
    Sequence Information (all 13)
    ORTHOLOGY for agk ( Chr: 18 )
    CITATIONS (26)