Gene

gnl3

ID

ZDB-GENE-030131-616

Name

G protein nucleolar 3

Symbol

gnl3 Nomenclature History

Previous Names

id:ibd2914
nstm (1)
nucleostemin
wu:fb38a04
wu:fc55d07
zgc:123093

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have GTP binding activity. Involved in several processes, including exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); neural retina development; and regulation of exit from mitosis. Predicted to localize to nucleolus. Is expressed in head; immature eye; midbrain; and somite. Orthologous to human GNL3 (G protein nucleolar 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnl3 Human Ortholog

No data available

Associated With gnl3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006073	GTP binding domain
Domain	IPR014813	Guanine nucleotide-binding protein-like 3, N-terminal domain
Domain	IPR030378	Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
Family	IPR050755	TRAFAC YlqF/YawG GTPases, Ribosome Maturation
Homologous_superfamily	IPR023179	GTP-binding protein, orthogonal bundle domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase