ZFIN ID: ZDB-GENE-030131-6152
Gene Name: matrix metallopeptidase 13b
Gene Symbol: mmp13b    Nomenclature History

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Previous Names: fi36g12, wu:fi36g12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Predicted to be involved in collagen catabolic process; endochondral ossification; and extracellular matrix disassembly. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); bone disease (multiple); and ovarian carcinoma. Orthologous to human MMP13 (matrix metallopeptidase 13).
Genome Resources: Alliance (1),  Gene:100006896 (1),  Ensembl(GRCz11):ENSDARG00000100794 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa562 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35941 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mmp13b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spondyloepimetaphyseal dysplasia, Missouri type Alliance Metaphyseal anadysplasia 1 602111
    Spondyloepimetaphyseal dysplasia, Missouri type 602111
    Metaphyseal dysplasia, Spahr type 250400
    DISEASE ASSOCIATED WITH mmp13b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process collagen catabolic process (more)
    Cellular Component extracellular matrix (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000585 Hemopexin-like domain
    Domain IPR001818 Peptidase M10, metallopeptidase
    Domain IPR002477 Peptidoglycan binding-like
    Domain IPR006026 Peptidase, metallopeptidase
    Conserved_site IPR018486 Hemopexin, conserved site
    Repeat IPR018487 Hemopexin-like repeats
    Family IPR021190 Peptidase M10A
    Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
    Family IPR028711 Collagenase 3
    Domain IPR033739 Peptidase M10A, catalytic domain
    Homologous_superfamily IPR036365 PGBD-like superfamily
    Homologous_superfamily IPR036375 Hemopexin-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mmp13b-201 (1)    Ensembl 2158
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mmp13b No data available
    MARKER RELATIONSHIPS
    mmp13b Contained in: [BAC] DKEY-26O16 (1) (order this)
    mmp13b Encodes: [EST] fi36g12
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001345471 (1)
    Genomic GenBank:CR855379 (1) 118248 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4ICX2 (1) 466 aa
    Sequence Information (all 9)
    ORTHOLOGY for mmp13b ( Chr: 15 )
    CITATIONS (23)