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ZIRC
ZFIN ID: ZDB-GENE-030131-6138
Gene Name: oxysterol binding protein-like 2b
Gene Symbol: osbpl2b    Nomenclature History

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Previous Names: osbpl2, wu:fi36a04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have cholesterol binding activity and sterol transporter activity. Predicted to be involved in lipid transport. Predicted to localize to the cytosol; intracellular membrane-bounded organelle; and membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 67. Is expressed in several structures, including blastodisc; digestive system; nervous system; otic vesicle; and yolk syncytial layer. Orthologous to human OSBPL2 (oxysterol binding protein like 2).
Genome Resources: Alliance (1),  Gene:334206 (1),  Ensembl(GRCz11):ENSDARG00000013830 (1)
GENE EXPRESSION
All Expression Data: 13 figures from 2 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2004 [MGC:55948]
  6 figures (11 images) from Thisse et al., 2004 [IMAGE:7153548]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa39398 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH osbpl2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 67 Alliance Deafness, autosomal dominant 67 616340
    DISEASE ASSOCIATED WITH osbpl2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lipid transport (more)
    Cellular Component cytosol (more)
    Molecular Function cholesterol binding (more)
    GO Terms (all 8)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA osbpl2b-201 (1)    Ensembl 2288
    osbpl2b-202 (1)    Ensembl 685
    osbpl2b-203 (1)    Ensembl 755
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM osbpl2b No data available
    MARKER RELATIONSHIPS
    osbpl2b Contained in: [BAC] DKEY-14P11 (1) (order this)
    osbpl2b Contains: [SNP] rs3729242 (1)
    osbpl2b Encodes: [EST] fi36a04, IMAGE:7153548 (1) (order this)
    [cDNA] MGC:55948 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199872 (1) 2291 bp
    Genomic GenBank:BX470099 (1) 199831 bp
    Select Tool
    Polypeptide UniProtKB:Q7ZVL1 (1) 472 aa
    Sequence Clusters UniGene:11569 (1)
    Sequence Information (all 22)
    ORTHOLOGY for osbpl2b ( Chr: 23 )
    CITATIONS (22)