ZFIN ID: ZDB-GENE-030131-6129
Gene Name: aldehyde dehydrogenase 7 family, member A1
Gene Symbol: aldh7a1    Nomenclature History

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Previous Names: ATQ (1), wu:fi34d12, wu:fi35e06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Involved in camera-type eye development; cartilage development; and pectoral fin development. Is expressed in several structures, including alar plate midbrain region; fin bud; musculature system; nervous system; and pharyngeal arch. Used to study epilepsy. Orthologous to human ALDH7A1 (aldehyde dehydrogenase 7 family member A1).
Genome Resources: Alliance (1),  Gene:334197 (1),  Ensembl(GRCz11):ENSDARG00000018426 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb297 Small Deletion Unknown Unknown CRISPR
ihb298 Small Deletion Unknown Unknown CRISPR
ot100 Insertion Exon 1 Premature Stop CRISPR
sa1371 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41611 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45400 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf2074 Small Deletion Unknown Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-aldh7a1 1
    CRISPR2-aldh7a1 1
    CRISPR3-aldh7a1 1
    MO1-aldh7a1 N/A 1
    MO2-aldh7a1 N/A 2
    MO3-aldh7a1 N/A 1
    MO4-aldh7a1 N/A 1
    DISEASE ASSOCIATED WITH aldh7a1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Epilepsy, pyridoxine-dependent 266100
    DISEASE ASSOCIATED WITH aldh7a1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    epilepsy aldh7a1ot100/ot100 standard conditions Pena et al., 2017
    aldh7a1zf2074/zf2074 standard conditions Zabinyakov et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process camera-type eye development (more)
    Molecular Function oxidoreductase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aldh7a1-201 (1)    Ensembl 1899
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aldh7a1 No data available
    MARKER RELATIONSHIPS
    aldh7a1 Contained in: [BAC] DKEY-184A18 (1) (order this)
    aldh7a1 Encodes: [EST] fi34d12, fi35e06
    [cDNA] MGC:55319 (1), MGC:192842 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212724 (1) 1822 nt
    Genomic GenBank:CR396586 (1) 225060 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QR17 (1) 541 aa
    Sequence Information (all 18)
    ORTHOLOGY for aldh7a1 ( Chr: 10 )
    CITATIONS (37)