ZFIN ID: ZDB-GENE-030131-6127
Gene Name: methionine adenosyltransferase I, alpha
Gene Symbol: mat1a

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Previous Name: wu:fi35e01

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Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 7 figures (9 images) from Thisse et al., 2004 [MGC:55442]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
  anterior neural tube, lens, liver, myotome (all 8) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2678 Point Mutation Unknown Premature Stop ENU
sa35458 Point Mutation Unknown Premature Stop ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mat1a HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Methionine adenosyltransferase deficiency, autosomal recessive 250850
Hypermethioninemia, persistent, autosomal dominant, due to methionine adenosyltransferase I/III deficiency 250850
GENE ONTOLOGY
Ontology GO Term
Biological Process S-adenosylmethionine biosynthetic process (more)
Cellular Component cytosol (more)
Molecular Function ATP binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002133 (1)
  • InterPro:IPR022628 (1)
  • InterPro:IPR022629 (1)
  • InterPro:IPR022630 (1)
  • InterPro:IPR022631 (1)
  • InterPro:IPR022636 (1)
  • PROSITE:PS00376 (1)
  • PROSITE:PS00377 (1)
  • Pfam:PF00438 (1)
  • Pfam:PF02772 (1)
  • Pfam:PF02773 (1)
  • EC:2.5.1.6 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA mat1a-001 (1) 2517
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM mat1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    mat1aContained in: [BAC] DKEY-250O4 (1) (order this)
    mat1aContains: [SNP] rs3728539 (1), rs3728540 (1), rs3728541 (1), rs3728542 (1)
    mat1aEncodes: [EST] fi35e01
    [cDNA] MGC:55442 (1) (order this), MGC:191659 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199871 (1) 2454bp
    Genomic GenBank:CR932438 (1) 56325bp
    Select Tool
    Polypeptide UniProtKB:Q7ZW04 (1) 390aa
    Sequence Clusters UniGene:76807 (1)
    Sequence Information (all 15)
    OTHER mat1a GENE PAGES
  • Gene:334195 (1)
  • VEGA:OTTDARG00000020692 (1)
  • Ensembl(GRCz10):ENSDARG00000039605 (1)
  • ORTHOLOGY for mat1a (Chr: 13)
    Species Symbol Chromosome Accession # Evidence
    Human MAT1A 10
  • Gene:4143
  • OMIM:610550
  • HGNC:6903
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (3)
    Mouse Mat1a 14
  • MGI:88017
  • Gene:11720
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (31)