ZFIN ID: ZDB-GENE-030131-6127
Gene Name: methionine adenosyltransferase I, alpha
Gene Symbol: mat1a
Previous Name: wu:fi35e01
Location: Chr: 13   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 7 figures (9 images) from Thisse et al., 2004 [MGC:55442]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
  anterior neural tube, lens, liver, myotome (all 8) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mat1a HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Hypermethioninemia, persistent, autosomal dominant, due to methionine adenosyltransferase I/III deficiency 250850
Methionine adenosyltransferase deficiency, autosomal recessive 250850
GENE ONTOLOGY
Ontology GO Term
Biological Process S-adenosylmethionine biosynthetic process (more)
Cellular Component cytosol (more)
Molecular Function ATP binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002133 (1)
  • InterPro:IPR022628 (1)
  • InterPro:IPR022629 (1)
  • InterPro:IPR022630 (1)
  • InterPro:IPR022631 (1)
  • InterPro:IPR022636 (1)
  • PROSITE:PS00376 (1)
  • PROSITE:PS00377 (1)
  • Pfam:PF00438 (1)
  • Pfam:PF02772 (1)
  • Pfam:PF02773 (1)
  • EC:2.5.1.6 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA mat1a-001 (1) 2517
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mat1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    mat1a Contained in: [BAC] DKEY-250O4 (1) (order this)
    mat1a Contains: [SNP] rs3728539 (1), rs3728540 (1), rs3728541 (1), rs3728542 (1)
    mat1a Encodes: [EST] fi35e01
    [cDNA] MGC:55442 (1) (order this), MGC:191659 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199871 (1) 2454 bp
    Genomic GenBank:CR932438 (1) 56325 bp
    Select Tool
    Polypeptide UniProtKB:Q7ZW04 (1) 390 aa
    Sequence Clusters UniGene:76807 (1)
    Sequence Information (all 15)
    OTHER mat1a GENE PAGES
  • Gene:334195 (1)
  • VEGA:OTTDARG00000020692 (1)
  • Ensembl(Zv9):ENSDARG00000039605 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish mat1a 13  
    Human MAT1A 10 (10q22)
  • OMIM:610550
  • Gene:4143
  • Mouse Mat1a 14 ( 22.36 cM)
  • MGI:88017
  • Gene:11720
  • Orthology Details
    CITATIONS (24)