ZFIN ID: ZDB-GENE-030131-6127
Gene Name: methionine adenosyltransferase I, alpha
Gene Symbol: mat1a
Previous Name: wu:fi35e01
Location: Chr: 13   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 7 figures (9 images) from Thisse et al., 2004 [MGC:55442]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
  anterior neural tube, lens, liver, myotome (all 8) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS No data available
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Hypermethioninemia, persistent, autosomal dominant, due to methionine adenosyltransferase I/III deficiency 250850
Methionine adenosyltransferase deficiency, autosomal recessive 250850
GENE ONTOLOGY
Ontology GO Term
Biological Process S-adenosylmethionine biosynthetic process (more)
Cellular Component cytosol (more)
Molecular Function ATP binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002133 (1)
  • InterPro:IPR022628 (1)
  • InterPro:IPR022629 (1)
  • InterPro:IPR022630 (1)
  • InterPro:IPR022631 (1)
  • InterPro:IPR022636 (1)
  • PROSITE:PS00376 (1)
  • PROSITE:PS00377 (1)
  • Pfam:PF00438 (1)
  • Pfam:PF02772 (1)
  • Pfam:PF02773 (1)
  • EC:2.5.1.6 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA mat1a-001 (1) 2517
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mat1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    mat1a Contained in: [BAC] DKEY-250O4 (1)
    mat1a Contains: [SNP] rs3728539 (1), rs3728540 (1), rs3728541 (1), rs3728542 (1)
    mat1a Encodes: [EST] fi35e01
    [cDNA] MGC:55442 (1) (order this), MGC:191659 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199871 (1) 2454 bp
    Genomic GenBank:CR932438 (1) 56325 bp
    Select Tool
    Polypeptide UniProtKB:Q7ZW04 (1) 390 aa
    Sequence Clusters UniGene:76807 (1)
    Sequence Information (all 15)
    OTHER mat1a GENE PAGES
  • Gene:334195 (1)
  • VEGA:OTTDARG00000020692 (1)
  • Ensembl(Zv9):ENSDARG00000039605 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish mat1a 13  
    Human MAT1A 10 (10q22)
  • OMIM:610550
  • Gene:4143
  • Mouse Mat1a 14 ( 22.36 cM)
  • MGI:88017
  • Gene:11720
  • Orthology Details
    CITATIONS (24)