Gene

ror1

ID
ZDB-GENE-030131-6104
Name
receptor tyrosine kinase-like orphan receptor 1
Symbol
ror1 Nomenclature History
Previous Names
  • fi34e02
  • si:dkey-209n16.1
  • wu:fi34e02 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have Wnt-protein binding activity. Predicted to be involved in positive regulation of intracellular signal transduction; positive regulation of kinase activity; and positive regulation of neuron projection development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in gonad. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 108. Orthologous to human ROR1 (receptor tyrosine kinase like orphan receptor 1).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from Bai et al., 2018
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ror1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 108 Alliance ?Deafness, autosomal recessive 108 617654
Associated With ror1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Conserved_site IPR018056 Kringle, conserved site
Domain IPR000001 Kringle
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR020067 Frizzled domain
Family IPR016247 Tyrosine-protein kinase, receptor ROR
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Homologous_superfamily IPR036790 Frizzled cysteine-rich domain superfamily
Homologous_superfamily IPR038178 Kringle superfamily
Domain Details Per Protein
Protein Length Frizzled cysteine-rich domain superfamily Frizzled domain Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Kringle Kringle, conserved site Kringle-like fold Kringle superfamily Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, receptor ROR
UniProtKB:F1QKB5 950
UniProtKB:A0A0B5JFH1 412
UniProtKB:A0A0R4IMU5 941
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations