Gene
ror1
- ID
- ZDB-GENE-030131-6104
- Name
- receptor tyrosine kinase-like orphan receptor 1
- Symbol
- ror1 Nomenclature History
- Previous Names
-
- fi34e02
- si:dkey-209n16.1
- wu:fi34e02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have Wnt-protein binding activity. Predicted to be involved in positive regulation of intracellular signal transduction; positive regulation of kinase activity; and positive regulation of neuron projection development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in gonad. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 108. Orthologous to human ROR1 (receptor tyrosine kinase like orphan receptor 1).
- Genome Resources
- Note
- None
- All Expression Data
- 2 figures from Bai et al., 2018
- Cross-Species Comparison
- High Throughput Data
- No data available
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 108 | Alliance | ?Deafness, autosomal recessive 108 | 617654 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR020067 | Frizzled domain |
| Family | IPR016247 | Tyrosine-protein kinase, receptor ROR |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036790 | Frizzled cysteine-rich domain superfamily |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
Domain Details Per Protein
| Protein | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype | Immunoglobulin subtype 2 | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, receptor ROR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QKB5
|
950 | |||||||||||||||||
|
UniProtKB:A0A0B5JFH1
|
412 | |||||||||||||||||
|
UniProtKB:A0A0R4IMU5
|
941 |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl