ZFIN ID: ZDB-GENE-030131-6101
Gene Name: ash1 (absent, small, or homeotic)-like (Drosophila)
Gene Symbol: ash1l    Nomenclature History

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Previous Names: fi34d11, si:ch211-81a5.3, wu:fi34d11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have several functions, including chromatin binding activity; histone-lysine N-methyltransferase activity; and metal ion binding activity. Predicted to be involved in chromatin remodeling. Predicted to localize to RSC-type complex. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 52. Orthologous to human ASH1L (ASH1 like histone lysine methyltransferase).
Genome Resources: Alliance (1),  Gene:563799 (1),  Ensembl(GRCz11):ENSDARG00000070981 (2)
GENE EXPRESSION
All Expression Data: Fig. S6 from Sun et al., 2008
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18097 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43225 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43226 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ash1l N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ash1l HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant mental retardation 52 Alliance Mental retardation, autosomal dominant 52 617796
    DISEASE ASSOCIATED WITH ash1l VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chromatin remodeling (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ash1l-202 (1)    Ensembl 9919
    ash1l-203 (1)    Ensembl 776
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ash1l No data available
    MARKER RELATIONSHIPS
    ash1l Contained in: [BAC] CH211-81A5 (1)
    ash1l Encodes: [EST] fi34d11
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001346407 (1)
    Genomic GenBank:CR626935 (1) 166134 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4J6P5 (1) 2988 aa
    Sequence Information (all 20)
    ORTHOLOGY for ash1l ( Chr: 19 )
    CITATIONS (20)