ZFIN ID: ZDB-GENE-030131-6032
Gene Name: LIM domain binding 3b
Gene Symbol: ldb3b    Nomenclature History

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Previous Names: ldb3l, wu:fi31d08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have actin binding activity and muscle alpha-actinin binding activity. Predicted to be involved in actin cytoskeleton organization; heart development; and muscle structure development. Predicted to localize to Z disc; actin cytoskeleton; and adherens junction. Is expressed in cardiovascular system; musculature system; and somite. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1C; distal myopathy; and myofibrillar myopathy 4. Orthologous to human LDB3 (LIM domain binding 3).
Genome Resources: Alliance (1),  Gene:334100 (1),  Ensembl(GRCz11):ENSDARG00000099974 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018168Tg Transgenic Insertion Unknown Unknown DNA
sa42038 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ldb3b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ldb3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy 1C Alliance Cardiomyopathy, dilated, 1C, with or without LVNC 601493
    Cardiomyopathy, hypertrophic, 24 601493
    Left ventricular noncompaction 3 601493
    myofibrillar myopathy 4 Alliance Myopathy, myofibrillar, 4 609452
    DISEASE ASSOCIATED WITH ldb3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process actin cytoskeleton organization (more)
    Cellular Component adherens junction (more)
    Molecular Function actin binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ldb3b-201 (1)    Ensembl 733
    ldb3b-202 (1)    Ensembl 948
    ldb3b-205 (1)    Ensembl 1655
    ldb3b-206 (1)    Ensembl 916
    ncRNA ldb3b-003 (1)    Ensembl 835
    ldb3b-005 (1)    Ensembl 761
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ldb3b No data available
    MARKER RELATIONSHIPS
    ldb3b Contained in: [BAC] CH211-103O20 (1), CH211-135B5 (1), CH211-214G6 (1)
    ldb3b Encodes: [EST] fi31d08
    [cDNA] MGC:55814 (1), MGC:77662 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199858 (1) 1743 nt
    Genomic GenBank:CR854941 (1) 204953 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q802V0 (1) 292 aa
    Sequence Information (all 26)
    ORTHOLOGY for ldb3b ( Chr: 12 )
    CITATIONS (24)