ZFIN ID: ZDB-GENE-030131-5928
Gene Name: bromodomain, testis-specific
Gene Symbol: brdt    Nomenclature History

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Previous Names: fi25h02, si:dkeyp-85h7.3, wu:fi25h02 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have lysine-acetylated histone binding activity. Predicted to be involved in histone displacement; male gamete generation; and regulation of RNA metabolic process. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated).
Genome Resources: Alliance (1),  Gene:333996 (1),  Ensembl(GRCz11):ENSDARG00000102802 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7159282]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20686 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33848 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-brdt N/A 1
    MO2-brdt N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH brdt HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spermatogenic failure 21 Alliance ?Spermatogenic failure 21 617644
    DISEASE ASSOCIATED WITH brdt VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process histone displacement (more)
    Cellular Component nucleus (more)
    Molecular Function lysine-acetylated histone binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA brdt-202 (1)    Ensembl 4819
    brdt-203 (1)    Ensembl 1050
    brdt-204 (1)    Ensembl 4691
    ncRNA brdt-003 (1)    Ensembl 782
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM brdt No data available
    MARKER RELATIONSHIPS
    brdt Contained in: [BAC] DKEYP-85H7 (1)
    brdt Contains: [SNP] rs3727970 (1), rs3727971 (1)
    brdt Encodes: [EST] fi25h02, IMAGE:2644102, IMAGE:7159282 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001305664 (1)
    Genomic GenBank:BX927081 (1) 137750 nt
    Select Tool
    Polypeptide UniProtKB:I3IS77 (1) 1093 aa
    Sequence Information (all 21)
    ORTHOLOGY for brdt ( Chr: 6 )
    CITATIONS (20)