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ZIRC
ZFIN ID: ZDB-GENE-030131-5911
Gene Name: protein tyrosine phosphatase non-receptor type 11a
Gene Symbol: ptpn11a
Sequence Ontology ID : SO:0000704

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Previous Names: ptpn11, fa14b09, shp2 (1), wu:fa14b09, wu:fi24f03, zgc:55388

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(Including Attributions)
Location: Chr: 10 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits protein tyrosine phosphatase activity. Involved in several processes, including cell population proliferation; convergent extension involved in axis elongation; and embryonic morphogenesis.  ...
GENE EXPRESSION
All Expression Data: 5 figures from 5 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55388]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3459 Point Mutation Exon 3 Premature Stop ENU
sa10099 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41576 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH ptpn11a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    juvenile myelomonocytic leukemia Leukemia, juvenile myelomonocytic, somatic 607785
    LEOPARD syndrome LEOPARD syndrome 1 151100
    Noonan syndrome 1 Noonan syndrome 1 163950
    Metachondromatosis 156250
    DISEASE ASSOCIATED WITH ptpn11a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell population proliferation (more)
    Cellular Component cytoplasm (more)
    Molecular Function phosphatase activity (more)
    GO Terms (all 16)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ptpn11a-201 (1) 3923
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ptpn11a
    MARKER RELATIONSHIPS
    ptpn11aContained in: [BAC] CH73-149O12 (1) (order this)
    ptpn11aEncodes: [EST] fa14b09, fi24f03
    [cDNA] MGC:55388 (1) (order this), MGC:191591 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199846 (1) 2118bp
    Genomic GenBank:CU570980 (1) 112134bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QL35 (1) 599aa
    Sequence Clusters UniGene:104919 (1)
    Sequence Information (all 27)
    ORTHOLOGY for ptpn11a (Chr: 10)
    CITATIONS (40)