ZFIN ID: ZDB-GENE-030131-5853
Gene Name: leucine rich repeat containing 8 VRAC subunit Aa
Gene Symbol: lrrc8aa    Nomenclature History

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Previous Names: lrrc8a, wu:fb18g12, wu:fi21b10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Exhibits volume-sensitive anion channel activity. Predicted to be involved in aspartate transmembrane transport; cellular response to osmotic stress; and taurine transport. Predicted to localize to cytoplasm; integral component of plasma membrane; and ion channel complex. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A).
Genome Resources: Alliance (1),  Gene:327642 (1),  Ensembl(GRCz11):ENSDARG00000032188 (2)
GENE EXPRESSION
All Expression Data: Fig. 6 from Yamada et al., 2016
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-lrrc8aa
1
CRISPR2-lrrc8aa
1
CRISPR3-lrrc8aa
1
CRISPR4-lrrc8aa
1
MO1-lrrc8aa N/A 1
MO2-lrrc8aa N/A 1
MO3-lrrc8aa N/A 1
MO4-lrrc8aa N/A 1
DISEASE ASSOCIATED WITH lrrc8aa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
agammaglobulinemia 5 Alliance ?Agammaglobulinemia 5 613506
DISEASE ASSOCIATED WITH lrrc8aa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component integral component of membrane (more)
Molecular Function volume-sensitive anion channel activity (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA lrrc8aa-201 (1)    Ensembl 3055
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM lrrc8aa No data available
MARKER RELATIONSHIPS
lrrc8aa Contained in: [BAC] CH73-224K16 (1), DKEY-84O3 (1) (order this)
lrrc8aa Contains: [SNP] rs3729066 (1)
lrrc8aa Encodes: [EST] fb18g12, fi21b10, fc59f07 (1)
[cDNA] MGC:114112 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001029949 (1) 3001 nt
Genomic GenBank:CT027677 (1) 193630 nt
Select Tool
Polypeptide UniProtKB:E9QIH3 (1) 795 aa
Sequence Information (all 15)
ORTHOLOGY for lrrc8aa ( Chr: 21 )
CITATIONS (24)