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Gene

spns2

ID
ZDB-GENE-030131-5843
Name
spinster homolog 2 (Drosophila)
Symbol
spns2 Nomenclature History
Previous Names
  • fi20h04
  • si:dkey-7b17.4
  • toh
  • wu:fi20h04
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable transmembrane transporter activity. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; embryonic organ development; and sphingosine-1-phosphate receptor signaling pathway. Predicted to be located in endosome membrane and plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including blastodisc; cardiovascular system; intermediate cell mass of mesoderm; tail bud; and yolk. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 115. Orthologous to human SPNS2 (sphingolipid transporter 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With spns2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 115 Alliance ?Deafness, autosomal recessive 115 618457
Associated With spns2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020846 Major facilitator superfamily domain
Family IPR011701 Major facilitator superfamily
Homologous_superfamily IPR036259 MFS transporter superfamily
Domain Details Per Protein
Protein Length Major facilitator superfamily Major facilitator superfamily domain MFS transporter superfamily
UniProtKB:G8JL22 579
UniProtKB:A0A2R8RTB0 489
UniProtKB:A9JRX4 105
UniProtKB:A2SWM2 504
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations