ZFIN ID: ZDB-GENE-030131-5838
Gene Name: CCR4-NOT transcription complex, subunit 3b
Gene Symbol: cnot3b    Nomenclature History

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Previous Names: cnot3, wu:fi20g07, zgc:55934

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have poly(A)-specific ribonuclease activity. Predicted to be involved in negative regulation of translation; nuclear-transcribed mRNA poly(A) tail shortening; and regulation of stem cell population maintenance. Predicted to localize to CCR4-NOT core complex and P-body. Is expressed in several structures, including gut; head; heart; integument; and testis. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3).
Genome Resources: Alliance (1),  Gene:327627 (1),  Ensembl(GRCz11):ENSDARG00000019842 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu195]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020569Tg Transgenic Insertion Unknown Unknown DNA
sa6547 Point Mutation Unknown Missense, Premature Stop ENU
sa9040 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10327 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15689 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23455 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23456 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cnot3b N/A 1
    PHENOTYPE
    Data: Fig. S2 from Delacruz et al., 2019
    Observed in:
    DISEASE ASSOCIATED WITH cnot3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Intellectual developmental disorder with speech delay, autism, and dysmorphic facies 618672
    DISEASE ASSOCIATED WITH cnot3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component CCR4-NOT core complex (more)
    Molecular Function poly(A)-specific ribonuclease activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cnot3b-202 (1)    Ensembl 3411
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cnot3b No data available
    MARKER RELATIONSHIPS
    cnot3b Contained in: [BAC] CH211-232M10 (1)
    cnot3b Encodes: [EST] eu195 (1), fi20g07
    [cDNA] MGC:55934 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199840 (1) 2946 nt
    Genomic GenBank:BX950195 (1) 149624 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZVL4 (1) 908 aa
    Sequence Information (all 20)
    ORTHOLOGY for cnot3b ( Chr: 19 )
    CITATIONS (29)