Gene

cnot3b

ID
ZDB-GENE-030131-5838
Name
CCR4-NOT transcription complex, subunit 3b
Symbol
cnot3b Nomenclature History
Previous Names
  • cnot3
  • wu:fi20g07
  • zgc:55934
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have poly(A)-specific ribonuclease activity. Predicted to be involved in negative regulation of translation; nuclear-transcribed mRNA poly(A) tail shortening; and regulation of stem cell population maintenance. Predicted to localize to CCR4-NOT core complex and P-body. Is expressed in several structures, including gut; head; heart; integument; and testis. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. S2 from Delacruz et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cnot3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Intellectual developmental disorder with speech delay, autism, and dysmorphic facies 618672
Associated With cnot3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR007207 CCR4-Not complex component, Not N-terminal domain
Domain IPR007282 NOT2/NOT3/NOT5, C-terminal
Family IPR012270 CCR4-NOT complex, subunit 3/ 5
Family IPR040168 Not2/Not3/Not5
Homologous_superfamily IPR038635 CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily
Domain Details Per Protein
Protein Length CCR4-Not complex component, Not N-terminal domain CCR4-NOT complex subunit 2/3/5, N-terminal domain superfamily CCR4-NOT complex, subunit 3/ 5 Not2/Not3/Not5 NOT2/NOT3/NOT5, C-terminal
UniProtKB:Q7ZVL4 908
UniProtKB:Q6TNV2 847
UniProtKB:Q1LUD8 885
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations