ZFIN ID: ZDB-GENE-030131-5812
Gene Name: ALG8 alpha-1,3-glucosyltransferase
Gene Symbol: alg8    Nomenclature History

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Previous Names: si:rp71-1p14.2, wu:fi19e09, wu:fi19f07 (1), zgc:112507

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein N-linked glycosylation. Predicted to localize to endoplasmic reticulum and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ih and polycystic liver disease. Orthologous to human ALG8 (ALG8 alpha-1,3-glucosyltransferase).
Genome Resources: Alliance (1),  Gene:327601 (1),  Ensembl(GRCz11):ENSDARG00000044627 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7159367]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13303 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14637 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15959 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29590 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH alg8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital disorder of glycosylation Ih Alliance Congenital disorder of glycosylation, type Ih 608104
    Polycystic liver disease 3 with or without kidney cysts 617874
    DISEASE ASSOCIATED WITH alg8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein N-linked glycosylation (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function glucosyltransferase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA alg8-201 (1)    Ensembl 1840
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alg8 No data available
    MARKER RELATIONSHIPS
    alg8 Contained in: [BAC] CH73-115D3 (1), RP71-1P14
    alg8 Encodes: [EST] fi19e09, fi19f07, fi19f09, IMAGE:7159367 (1)
    [cDNA] MGC:112507 (1), MGC:191862 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001017647 (1) 1857 nt
    Genomic GenBank:AL627325 163882 nt
    Select Tool
    Polypeptide UniProtKB:Q566T2 (1) 524 aa
    Sequence Information (all 20)
    ORTHOLOGY for alg8 ( Chr: 21 )
    CITATIONS (24)