Gene

mthfd2l

ID
ZDB-GENE-030131-5707
Name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
Symbol
mthfd2l Nomenclature History
Previous Names
  • wu:fi14c12
  • zgc:63479
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to localize to mitochondrion. Is expressed in anterior neural tube and optic cup. Orthologous to human MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Lee et al., 2012
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mthfd2l Human Ortholog
No data available
Associated With mthfd2l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
Domain IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Domain IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Family IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length NAD(P)-binding domain superfamily Tetrahydrofolate dehydrogenase/cyclohydrolase Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
UniProtKB:F1QXT9 334
UniProtKB:E9QC23 295
UniProtKB:Q7SY55 334
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations