Gene

cars2

ID
ZDB-GENE-030131-5564
Name
cysteinyl-tRNA synthetase 2, mitochondrial
Symbol
cars2 Nomenclature History
Previous Names
  • fi04c12
  • si:ch211-198k9.5
  • wu:fi04c12 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and cysteine-tRNA ligase activity. Involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 27. Orthologous to human CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Wang et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cars2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined oxidative phosphorylation deficiency 27 Alliance Combined oxidative phosphorylation deficiency 27 616672
Associated With cars2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR032678 tRNA synthetases class I, catalytic domain
Family IPR015803 Cysteine-tRNA ligase
Family IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase
Homologous_superfamily IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ia, anticodon-binding Cysteine-tRNA ligase Cysteinyl-tRNA synthetase/mycothiol ligase Rossmann-like alpha/beta/alpha sandwich fold tRNA synthetases class I, catalytic domain
UniProtKB:E7FC09 566
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations